Combining Asenapine and Cannabis: Potential Interactions and Risks

If you are taking asenapine, a medication commonly prescribed for schizophrenia and bipolar disorder, and considering using cannabis (marijuana), it’s crucial to understand the potential interactions and risks. Combining these substances may lead to increased side effects or reduced effectiveness of your medication. Always consult your healthcare provider before using cannabis or any other substances while taking prescription medications.

Potential Concerns and Risks

  1. Enhanced Drowsiness and Sedation: Asenapine and cannabis can both cause drowsiness and sedation. When used together, these effects may be intensified, leading to increased tiredness, difficulty concentrating, and impaired alertness for tasks like driving or operating machinery.
  2. Heightened Risk of Psychosis: Cannabis use, particularly high-THC strains, has been linked to an increased risk of acute psychosis or exacerbation of existing psychotic symptoms in some individuals. Combining cannabis with asenapine, an antipsychotic medication, may counteract the therapeutic effects of the medication and worsen schizophrenia or bipolar disorder symptoms.
  3. Cognitive and Memory Impairment: Both cannabis and asenapine can affect cognitive function and memory. Using these substances together might result in more significant cognitive impairments, potentially impacting daily activities and overall quality of life.
  4. Increased Anxiety: Cannabis use can cause increased anxiety or paranoia in some people. When combined with asenapine, this effect might be more pronounced, particularly in individuals with a predisposition to anxiety or a history of anxiety disorders.

Consult Your Healthcare Provider

It’s essential to discuss your cannabis use with your healthcare provider. They can provide personalized advice based on your medical history, current medications, and specific health needs. Your provider may recommend adjusting your treatment plan, monitoring your symptoms more closely, or exploring alternative treatments to ensure your safety and well-being.


There are various forms of drugs available, such as tablets or liquids, and each may have a separate patient information leaflet (PIL) for different doses. It is important to refer to the PIL for the specific form and dose of the drug that you have been prescribed.

You can search for further information and PILs on websites such as:

What does Asenapine (Saphris) do?

Asenapine Transdermal Patch: A Novel Approach to Antipsychotic Treatment

2 thoughts on “Combining Asenapine and Cannabis: Potential Interactions and Risks”

  1. I’m 35 years old and have been dealing with bipolar disorder for several years now. I’ve been taking asenapine to manage my symptoms, but sometimes I still struggle with sleeping and anxiety. After talking to my psychiatrist, I decided to give cannabis a try to see if it could help me relax in the evenings and get better sleep.

    I started with a low-THC, high-CBD strain of cannabis, known for its calming effects and lower risk of triggering anxiety or paranoia. To minimize potential risks associated with smoking, I chose to use a vaporizer. I began with a small dose and slowly increased it, paying close attention to how my body and mind responded to the cannabis.

    Over time, I noticed that using cannabis in the evenings helped me relax, reduced my anxiety, and improved my sleep quality. The combination of asenapine and cannabis seemed to work well for me, and I was able to maintain my daily routine without any significant side effects. I made sure to stay open with my psychiatrist about my cannabis use, and together, we closely monitored my mental health to ensure that the combination remained safe and effective.

    • Dear John,

      Thank you for sharing your personal experience with using cannabis alongside asenapine to manage your bipolar disorder symptoms. It’s great to hear that you’ve found a combination that works for you and that you have noticed improvements in your anxiety and sleep quality.

      It’s also commendable that you’ve been open with your psychiatrist about your cannabis use, and you have been closely monitoring your mental health. Regular communication with your healthcare provider is essential for ensuring the safety and effectiveness of your treatment plan.

      While your experience is positive, it’s important to remember that everyone’s situation is unique, and what works for one person may not work for another. For anyone considering using cannabis while taking asenapine or other medications, it’s crucial to consult with a healthcare professional before making any changes to their treatment plan.

      Thanks again for sharing, John, and we appreciate your contribution to the discussion. Wishing you continued success in managing your symptoms and maintaining your well-being.

      Best regards,

      Azspills Team

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