Benperidol was one of the first antipsychotics introduced for the treatment of schizophrenia and other psychotic disorders. However, its use today is very limited due to intolerable side effects and safety issues. Fortunately, there are many newer antipsychotic medications now available that offer improved efficacy and tolerability compared to older drugs like benperidol. Atypical antipsychotics … Read more about Alternatives to Benperidol: Newer, Safer Treatment Options
Extrapyramidal side effects Benperidol High risk of extrapyramidal side effects due to potent D2 antagonism. Can cause dystonia, akathisia, parkinsonism, and tardive dyskinesia, especially at high doses. Clozapine Low risk of extrapyramidal side effects due to weaker D2 antagonism and additional 5-HT2A antagonism. Rarely causes movement disorders even at high doses. Sedation and drowsiness Benperidol … Read more about Benperidol vs Clozapine Side Effects
Dopamine receptor antagonism The primary action of benperidol is blockade of dopamine D2 receptors in the brain. This inhibits dopaminergic neurotransmission, especially in the mesolimbic pathway. Hyperactivity of this pathway is associated with positive symptoms of psychosis such as delusions, hallucinations, and disorganized thinking. By blocking D2 receptors, benperidol interferes with this hyperactive dopaminergic signaling, … Read more about How does Benperidol work?
Extrapyramidal side effects Benperidol can cause extrapyramidal side effects due to its dopamine receptor blocking effects. These include: Orthostatic hypotension Due to its alpha-adrenergic blocking effects, benperidol may cause a drop in blood pressure upon standing from sitting or lying down. Can lead to dizziness, lightheadedness and falls. Patient should change positions slowly. Blood pressure … Read more about What are the side effects of the drug Benperidol?
Hypersensitivity Benperidol is contraindicated in patients with known hypersensitivity to the drug or any components of its formulation. Reactions may include rash, itching, swelling, and bronchospasm. Parkinson’s disease Benperidol can worsen symptoms of Parkinson’s disease due to its blockade of dopamine receptors. It is therefore contraindicated in patients with Parkinson’s disease. Depression Benperidol may worsen … Read more about What are the contraindications for Benperidol?
Oral Dosing for benperidol Benperidol is available as oral tablets of 1 mg, 2 mg, and 5 mg. Due to its long half-life and poor bioavailability, benperidol must be administered 2-3 times daily to achieve sustained antipsychotic effect. For schizophrenia, the initial dose is usually 2-10 mg orally 2-3 times per day. The dose is … Read more about What is the dosing for benperidol?
Absorption of Benperidol Benperidol is well absorbed after oral administration. It undergoes extensive first-pass metabolism in the liver, resulting in low systemic bioavailability of approximately 20-30%. This means that a large portion of an oral dose is metabolized before reaching systemic circulation. Peak plasma concentrations are achieved 3-6 hours after an oral dose. Distribution of … Read more about What are the pharmacokinetics of Benperidol?
Benperidol is a typical first-generation antipsychotic. It belongs to the chemical class of butyrophenones, a group of antipsychotics with a similar chemical core of phenylbutyrophenone. Benperidol was first introduced in the late 1950s and was one of the first neuroleptics used to treat psychoses such as schizophrenia. Benperidol and other typical first-generation antipsychotics work primarily … Read more about What type of drug is benperidol?
Benperidol is a typical first-generation neuroleptic with the chemical name 3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2- a]pyrimidin-4-one. It is a piperazine phenylisoxazole derivative. Benperidol consists of a central piperazine ring attached at one side to a phenylisoxazole unit and at the other side to a tetrahydropyridopyrimidine. The phenylene ring of the phenylisoxazole is substituted with fluorine at the 6-position. This … Read more about What is the structure of Benperidol?
Primary Use: Treating Schizophrenia and Psychotic Disorders Benperidol is an antipsychotic medication primarily used for treating schizophrenia and other psychotic disorders. It belongs to the butyrophenone class of drugs, which work by blocking dopamine receptors in the brain, thereby reducing psychotic symptoms such as hallucinations, delusions, and disorganized thinking. Clinical Studies Numerous studies have investigated … Read more about What is benperidol used for?