Amitriptyline and Gabapentin: A Study of Interactions and Combinations

As we delve into the intricate realm of pharmaceuticals, two names that often intermingle are Amitriptyline and Gabapentin. These medications, primarily used for managing neuropathic pain, depression, and several other neurological conditions, are often utilized in combination for their synergistic potentials.

This blog post aims to shed light on the various interactions and combinations involving these two medications, their usage in different formulations such as creams, and their co-administration with other drugs. It’s crucial to remember that while this post provides valuable insights, it’s not a substitute for professional medical advice.

Amitriptyline and Gabapentin: A Common Duo

Amitriptyline is a tricyclic antidepressant, while Gabapentin is an anticonvulsant. Together, they form a dynamic duo in combating neuropathic pain. Several studies, including those found on nih.gov, have acknowledged the effectiveness of the amitriptyline gabapentin combination in managing conditions like fibromyalgia and post-herpetic neuralgia.

Moreover, this combination therapy is also seen in conjunction with other medications. For example, amitriptyline gabapentin duloxetine combination therapy is sometimes used for managing complex neuropathic pain conditions. Duloxetine, another antidepressant, adds to the therapeutic potential of this combination.

Topical Applications: Adding Lidocaine, Ketoprofen, and More to the Mix

Amitriptyline and Gabapentin are not limited to oral administration. They are also included in various topical formulations, often alongside other medications. One such example is amitriptyline gabapentin lidocaine cream. Lidocaine, an anesthetic, aids in providing immediate pain relief, while Amitriptyline and Gabapentin work to manage the underlying neuropathic pain.

The cream can also contain other agents like ketoprofen, a nonsteroidal anti-inflammatory drug (NSAID), and flurbiprofen. These additions aim to enhance the cream’s anti-inflammatory and analgesic properties. In some cases, other medications like cyclobenzaprine (a muscle relaxant) or prilocaine (another anesthetic) can be included.

Interactions: Amitriptyline, Gabapentin, and Other Medications

When combined with other medications, the interactions become more complex. For instance, mixing carvedilol amitriptyline gabapentin and lorazepam requires careful medical supervision. Carvedilol, a beta-blocker, and Lorazepam, a benzodiazepine, can both interact with Amitriptyline and Gabapentin, possibly leading to side effects like drowsiness and dizziness.

Similarly, combining buspirone mixed with amitriptyline gabapentin or administering amitriptyline gabapentin cymbalta needs to be done under strict medical guidance due to potential drug-drug interactions.

Even when taking copaxone with morphine hydrocodone amitriptyline gabapentin, which could be prescribed for conditions like Multiple Sclerosis with associated pain, it’s crucial to keep a medical professional in the loop to monitor for any adverse effects or interactions.

In Conclusion

Whether it’s amitriptyline gabapentin lidocaine in a cream or propranolol meperidine amitriptyline gabapentin in a regimen to manage pain, these combinations indicate the multifaceted role of Amitriptyline and Gabapentin in patient care. However, all these combinations require a nuanced understanding of pharmacology and should only be taken under medical supervision.

As we continue to explore the potential of these drugs in pain management and beyond, it’s crucial to remember the importance of personalized medicine. After all, every individual reacts to medication differently, and the best therapeutic approach is one that considers a patient’s unique medical history, current health status, and long-term wellness goals.


There are various forms of drugs available, such as tablets or liquids, and each may have a separate patient information leaflet (PIL) for different doses. It is important to refer to the PIL for the specific form and dose of the drug that you have been prescribed.

You can search for further information and PILs on websites such as:

  • The British National Formulary (BNF)
  • Electronic medicines compendium (emc)
  • The National Library of Medicine's DailyMed
  • The Food and Drug Administration (FDA) 
  • Different drug forms like tablets or liquids have specific patient information leaflets (PIL) for various doses. Refer to the PIL for your prescribed drug form and dose.

    Search for PILs on websites like:

    France

    • ANSM (Agence nationale de sécurité du médicament et des produits de santé): ansm.sante.fr

    Spain

    • AEMPS (Agencia Española de Medicamentos y Productos Sanitarios): aemps.gob.es

    Germany

    • BfArM (Bundesinstitut für Arzneimittel und Medizinprodukte): bfarm.de

    Italy

    For questions about your medication:

    • Consult your doctor, a healthcare professional, or a pharmacist

    France

    • Contact SOS Médecins: 3624
    • For mental health support, contact SOS Suicide: 01 45 39 40 00

    Belgium (French)

    Switzerland (French)

    • La Main Tendue: 143
    • Website: 143.ch

    Canada (French)

    • Centre de prévention du suicide du Québec: 1 866 APPELLE (1 866 277-3553)
    • Website: cpsquebec.ca

    Spain

    • Contact emergency number: 112
    • For mental health support, contact Teléfono de la Esperanza: 717 003 717

    Germany

    • Contact emergency number: 112
    • For mental health support, contact Telefonseelsorge: 0800 111 0 111 or 0800 111 0 222

    Italy

    • Contact emergency number: 112
    • For mental health support, contact Telefono Amico: 199 284 284

    Netherlands

    • Contact emergency number: 112
    • For mental health support, contact 113 Zelfmoordpreventie: 0800 0113

    Portugal

    • Contact emergency number: 112
    • For mental health support, contact Sos Voz Amiga: 21 354 45 45, 91 280 26 69, or 96 352 46 60

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