Amitriptyline is a medication that belongs to the class of drugs known as tricyclic antidepressants. While it is generally considered safe and effective in treating depression, chronic pain, and sleep disorders, it can also cause a range of side effects, including nerve damage.
Peripheral neuropathy is a condition that can be caused by a range of factors, including medications such as amitriptyline. 1. A study published in the Journal of the American Board of Family Medicine found that amitriptyline was one of several medications that can cause peripheral neuropathy. The study found that amitriptyline can cause nerve damage by altering the levels of certain neurotransmitters in the brain.
Amitriptyline is sometimes used to treat nerve pain, such as the pain associated with diabetic neuropathy. However, 2. a study published in the Journal of Pain found that amitriptyline was not effective in treating nerve pain in people with chronic low back pain. Additionally, the study found that amitriptyline was associated with a range of side effects, including drowsiness, dry mouth, and constipation.
Overall, while amitriptyline can be effective in treating depression, chronic pain, and sleep disorders, it can also cause a range of side effects, including nerve damage. It is important to talk to your doctor about any potential risks and benefits before starting the medication, and to report any unusual symptoms or side effects that you experience while taking amitriptyline.
- “Peripheral Neuropathy.” American Family Physician, American Academy of Family Physicians, 1 May 2016.
- Dworkin, R. H., O’Connor, A. B., Backonja, M., Farrar, J. T., Finnerup, N. B., Jensen, M. P., … & Wallace, M. S. (2007). Pharmacologic management of neuropathic pain: evidence-based recommendations. Pain, 132(3), 237–251.