How Long Does It Take for Pregabalin to Kick In?

Pregabalin is a medication that is often used to treat conditions such as neuropathic pain, fibromyalgia, and anxiety disorders. One of the most common questions people have about this medication is how quickly it starts to work. In this article, we’ll take a closer look at how long it takes for pregabalin to kick in, and what factors can affect its onset of action.

How Pregabalin Works

Before we discuss how long it takes for pregabalin to kick in, it’s helpful to understand how the medication works. Pregabalin is an anticonvulsant drug that is believed to work by reducing the levels of certain neurotransmitters in the brain and nervous system. These neurotransmitters, which include glutamate, substance P, and norepinephrine, are involved in the sensation of pain, anxiety, and other symptoms that pregabalin is used to treat.

By reducing the levels of these neurotransmitters, pregabalin can help to dampen the signals that cause pain, anxiety, and other symptoms, providing relief for people with conditions like neuropathy and fibromyalgia. However, the onset of action for pregabalin can vary depending on several factors.

Factors That Affect Pregabalin’s Onset of Action

The amount of time it takes for pregabalin to kick in can depend on several factors, including:

  • The dosage of pregabalin prescribed: Higher doses of pregabalin may provide more rapid symptom relief than lower doses.
  • The individual’s tolerance: Some people may be more sensitive to the effects of pregabalin than others, which can affect how quickly they feel relief.
  • The underlying condition being treated: Pregabalin may work more quickly for some conditions than for others.

Typical Timeline for Pregabalin’s Onset of Action

While the timeline for pregabalin’s onset of action can vary, some studies have shown that the medication can start to provide symptom relief within the first week of treatment. For example, a study published in the journal Pain found that pregabalin was effective in reducing pain intensity in patients with fibromyalgia, with the most significant pain relief occurring after 2-3 weeks of treatment.

In another study published in the journal Current Medical Research and Opinion, researchers found that pregabalin was effective in reducing anxiety symptoms in patients with generalized anxiety disorder, with significant improvements seen after just one week of treatment.

It’s important to note that individual results may vary, and some people may experience faster or slower symptom relief than others. Additionally, it’s important to follow the dosage and usage instructions provided by your healthcare provider and not to exceed the recommended dose.

Conclusion

Pregabalin is a medication that is often used to treat conditions like neuropathic pain, fibromyalgia, and anxiety disorders. While the timeline for pregabalin’s onset of action can vary depending on several factors, some studies have shown that it can start to provide symptom relief within the first week of treatment. However, individual results may vary, and it’s important to follow the dosage and usage instructions provided by your healthcare provider. If you are currently taking pregabalin and are not experiencing relief, you should consult with your healthcare provider to discuss other treatment options.


There are various forms of drugs available, such as tablets or liquids, and each may have a separate patient information leaflet (PIL) for different doses. It is important to refer to the PIL for the specific form and dose of the drug that you have been prescribed.

You can search for further information and PILs on websites such as:

  • The British National Formulary (BNF)
  • Electronic medicines compendium (emc)
  • The National Library of Medicine's DailyMed
  • The Food and Drug Administration (FDA) 
  • Different drug forms like tablets or liquids have specific patient information leaflets (PIL) for various doses. Refer to the PIL for your prescribed drug form and dose.

    Search for PILs on websites like:

    France

    • ANSM (Agence nationale de sécurité du médicament et des produits de santé): ansm.sante.fr

    Spain

    • AEMPS (Agencia Española de Medicamentos y Productos Sanitarios): aemps.gob.es

    Germany

    • BfArM (Bundesinstitut für Arzneimittel und Medizinprodukte): bfarm.de

    Italy

    For questions about your medication:

    • Consult your doctor, a healthcare professional, or a pharmacist

    France

    • Contact SOS Médecins: 3624
    • For mental health support, contact SOS Suicide: 01 45 39 40 00

    Belgium (French)

    Switzerland (French)

    • La Main Tendue: 143
    • Website: 143.ch

    Canada (French)

    • Centre de prévention du suicide du Québec: 1 866 APPELLE (1 866 277-3553)
    • Website: cpsquebec.ca

    Spain

    • Contact emergency number: 112
    • For mental health support, contact Teléfono de la Esperanza: 717 003 717

    Germany

    • Contact emergency number: 112
    • For mental health support, contact Telefonseelsorge: 0800 111 0 111 or 0800 111 0 222

    Italy

    • Contact emergency number: 112
    • For mental health support, contact Telefono Amico: 199 284 284

    Netherlands

    • Contact emergency number: 112
    • For mental health support, contact 113 Zelfmoordpreventie: 0800 0113

    Portugal

    • Contact emergency number: 112
    • For mental health support, contact Sos Voz Amiga: 21 354 45 45, 91 280 26 69, or 96 352 46 60

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