Paliperidone, like all medications, can interact with other drugs, supplements, and substances. It’s important to be aware of potential interactions in order to avoid any harmful effects or reduced effectiveness of the medication. Here are some common drug interactions with paliperidone:
Carbamazepine
Carbamazepine can reduce the effectiveness of paliperidone by increasing its metabolism and clearance from the body.
Fluoxetine
Fluoxetine can increase the levels of paliperidone in the body, which can increase the risk of side effects.
Ketoconazole
Ketoconazole can increase the levels of paliperidone in the body, which can increase the risk of side effects.
Antihypertensive drugs
Paliperidone can cause orthostatic hypotension (a sudden drop in blood pressure when standing up), which can be exacerbated by antihypertensive medications.
CNS depressants
Paliperidone can cause sedation, which can be exacerbated by other medications that have sedative effects, such as benzodiazepines and opioids.
It’s important to inform your healthcare provider of all medications, supplements, and substances you are taking before starting paliperidone, as well as any changes to your medication regimen. Your healthcare provider can help you determine if there are any potential interactions and adjust your medication accordingly.
In addition, it’s important to avoid drinking alcohol while taking paliperidone, as alcohol can increase the sedative effects of the medication and increase the risk of side effects.
Overall, while paliperidone is an effective medication for treating symptoms of schizophrenia and related conditions, it’s important to be aware of potential interactions and to work closely with a healthcare provider to ensure safe and effective treatment.