Paliperidone Interactions: What You Need to Know

Paliperidone, like all medications, can interact with other drugs, supplements, and substances. It’s important to be aware of potential interactions in order to avoid any harmful effects or reduced effectiveness of the medication. Here are some common drug interactions with paliperidone:

Carbamazepine

Carbamazepine can reduce the effectiveness of paliperidone by increasing its metabolism and clearance from the body.

Fluoxetine

Fluoxetine can increase the levels of paliperidone in the body, which can increase the risk of side effects.

Ketoconazole

Ketoconazole can increase the levels of paliperidone in the body, which can increase the risk of side effects.

Antihypertensive drugs

Paliperidone can cause orthostatic hypotension (a sudden drop in blood pressure when standing up), which can be exacerbated by antihypertensive medications.

CNS depressants

Paliperidone can cause sedation, which can be exacerbated by other medications that have sedative effects, such as benzodiazepines and opioids.

It’s important to inform your healthcare provider of all medications, supplements, and substances you are taking before starting paliperidone, as well as any changes to your medication regimen. Your healthcare provider can help you determine if there are any potential interactions and adjust your medication accordingly.

In addition, it’s important to avoid drinking alcohol while taking paliperidone, as alcohol can increase the sedative effects of the medication and increase the risk of side effects.

Overall, while paliperidone is an effective medication for treating symptoms of schizophrenia and related conditions, it’s important to be aware of potential interactions and to work closely with a healthcare provider to ensure safe and effective treatment.


There are various forms of drugs available, such as tablets or liquids, and each may have a separate patient information leaflet (PIL) for different doses. It is important to refer to the PIL for the specific form and dose of the drug that you have been prescribed.

You can search for further information and PILs on websites such as:

  • The British National Formulary (BNF)
  • Electronic medicines compendium (emc)
  • The National Library of Medicine's DailyMed
  • The Food and Drug Administration (FDA) 
  • Different drug forms like tablets or liquids have specific patient information leaflets (PIL) for various doses. Refer to the PIL for your prescribed drug form and dose.

    Search for PILs on websites like:

    France

    • ANSM (Agence nationale de sécurité du médicament et des produits de santé): ansm.sante.fr

    Spain

    • AEMPS (Agencia Española de Medicamentos y Productos Sanitarios): aemps.gob.es

    Germany

    • BfArM (Bundesinstitut für Arzneimittel und Medizinprodukte): bfarm.de

    Italy

    For questions about your medication:

    • Consult your doctor, a healthcare professional, or a pharmacist

    France

    • Contact SOS Médecins: 3624
    • For mental health support, contact SOS Suicide: 01 45 39 40 00

    Belgium (French)

    Switzerland (French)

    • La Main Tendue: 143
    • Website: 143.ch

    Canada (French)

    • Centre de prévention du suicide du Québec: 1 866 APPELLE (1 866 277-3553)
    • Website: cpsquebec.ca

    Spain

    • Contact emergency number: 112
    • For mental health support, contact Teléfono de la Esperanza: 717 003 717

    Germany

    • Contact emergency number: 112
    • For mental health support, contact Telefonseelsorge: 0800 111 0 111 or 0800 111 0 222

    Italy

    • Contact emergency number: 112
    • For mental health support, contact Telefono Amico: 199 284 284

    Netherlands

    • Contact emergency number: 112
    • For mental health support, contact 113 Zelfmoordpreventie: 0800 0113

    Portugal

    • Contact emergency number: 112
    • For mental health support, contact Sos Voz Amiga: 21 354 45 45, 91 280 26 69, or 96 352 46 60

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