Paliperidone Palmitate: A Long-Acting Formulation of an Atypical Antipsychotic

Paliperidone palmitate is a long-acting injectable formulation of the atypical antipsychotic medication paliperidone. It is used to treat schizophrenia and related conditions in adults.

Paliperidone palmitate is administered by injection into the muscle, typically once a month or every three months depending on the individual’s needs. The medication is slowly released into the bloodstream over time, providing continuous medication delivery and reducing the need for daily dosing.

Paliperidone palmitate has several advantages over oral formulations of paliperidone. It can improve medication adherence by reducing the burden of daily dosing, and it may reduce the risk of relapse by providing continuous medication delivery. Additionally, paliperidone palmitate has a lower risk of causing gastrointestinal side effects than some other long-acting injectable antipsychotic medications.

As with all medications, paliperidone palmitate can cause side effects. Common side effects include injection site reactions, weight gain, and movement disorders. It’s important to work closely with a healthcare provider when taking paliperidone palmitate and to report any side effects or concerns promptly.

In conclusion, paliperidone palmitate is a long-acting injectable formulation of the atypical antipsychotic medication paliperidone. It is an effective treatment option for individuals with schizophrenia and related conditions, providing continuous medication delivery and reducing the need for daily dosing. If you are considering paliperidone palmitate as a treatment option, talk to your healthcare provider about whether it is right for you.


There are various forms of drugs available, such as tablets or liquids, and each may have a separate patient information leaflet (PIL) for different doses. It is important to refer to the PIL for the specific form and dose of the drug that you have been prescribed.

You can search for further information and PILs on websites such as: