Paliperidone Palmitate: A Long-Acting Formulation of an Atypical Antipsychotic

Paliperidone palmitate is a long-acting injectable formulation of the atypical antipsychotic medication paliperidone. It is used to treat schizophrenia and related conditions in adults.

Paliperidone palmitate is administered by injection into the muscle, typically once a month or every three months depending on the individual’s needs. The medication is slowly released into the bloodstream over time, providing continuous medication delivery and reducing the need for daily dosing.

Paliperidone palmitate has several advantages over oral formulations of paliperidone. It can improve medication adherence by reducing the burden of daily dosing, and it may reduce the risk of relapse by providing continuous medication delivery. Additionally, paliperidone palmitate has a lower risk of causing gastrointestinal side effects than some other long-acting injectable antipsychotic medications.

As with all medications, paliperidone palmitate can cause side effects. Common side effects include injection site reactions, weight gain, and movement disorders. It’s important to work closely with a healthcare provider when taking paliperidone palmitate and to report any side effects or concerns promptly.

In conclusion, paliperidone palmitate is a long-acting injectable formulation of the atypical antipsychotic medication paliperidone. It is an effective treatment option for individuals with schizophrenia and related conditions, providing continuous medication delivery and reducing the need for daily dosing. If you are considering paliperidone palmitate as a treatment option, talk to your healthcare provider about whether it is right for you.


There are various forms of drugs available, such as tablets or liquids, and each may have a separate patient information leaflet (PIL) for different doses. It is important to refer to the PIL for the specific form and dose of the drug that you have been prescribed.

You can search for further information and PILs on websites such as:

  • The British National Formulary (BNF)
  • Electronic medicines compendium (emc)
  • The National Library of Medicine's DailyMed
  • The Food and Drug Administration (FDA) 
  • Different drug forms like tablets or liquids have specific patient information leaflets (PIL) for various doses. Refer to the PIL for your prescribed drug form and dose.

    Search for PILs on websites like:

    France

    • ANSM (Agence nationale de sécurité du médicament et des produits de santé): ansm.sante.fr

    Spain

    • AEMPS (Agencia Española de Medicamentos y Productos Sanitarios): aemps.gob.es

    Germany

    • BfArM (Bundesinstitut für Arzneimittel und Medizinprodukte): bfarm.de

    Italy

    For questions about your medication:

    • Consult your doctor, a healthcare professional, or a pharmacist

    France

    • Contact SOS Médecins: 3624
    • For mental health support, contact SOS Suicide: 01 45 39 40 00

    Belgium (French)

    Switzerland (French)

    • La Main Tendue: 143
    • Website: 143.ch

    Canada (French)

    • Centre de prévention du suicide du Québec: 1 866 APPELLE (1 866 277-3553)
    • Website: cpsquebec.ca

    Spain

    • Contact emergency number: 112
    • For mental health support, contact Teléfono de la Esperanza: 717 003 717

    Germany

    • Contact emergency number: 112
    • For mental health support, contact Telefonseelsorge: 0800 111 0 111 or 0800 111 0 222

    Italy

    • Contact emergency number: 112
    • For mental health support, contact Telefono Amico: 199 284 284

    Netherlands

    • Contact emergency number: 112
    • For mental health support, contact 113 Zelfmoordpreventie: 0800 0113

    Portugal

    • Contact emergency number: 112
    • For mental health support, contact Sos Voz Amiga: 21 354 45 45, 91 280 26 69, or 96 352 46 60

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