Paliperidone Side Effects: What You Need to Know

Paliperidone is a medication used to treat symptoms of schizophrenia and related conditions. While it can be an effective treatment option, it’s important to be aware of potential side effects.

Here are some common side effects of paliperidone:

  1. Weight gain: Paliperidone can cause weight gain, which can be a concern for some individuals. One study found that patients taking paliperidone had an average weight gain of 1.5 kg over a 12-week period.
  2. Sedation: Paliperidone can cause sedation, which can make it difficult to perform daily activities. A study found that paliperidone caused significant sedation in some patients compared to other antipsychotic medications.
  3. Movement disorders: Paliperidone can cause movement disorders such as akathisia, tremors, and dystonia. A study found that paliperidone was associated with a higher incidence of akathisia compared to other antipsychotic medications.
  4. Cardiovascular effects: Paliperidone can cause changes in heart rate and blood pressure. One study found that paliperidone caused a slight increase in heart rate in some patients.
  5. Metabolic effects: Paliperidone can cause changes in blood sugar, cholesterol, and triglyceride levels. A study found that paliperidone was associated with an increase in fasting blood glucose levels in some patients.

It’s important to note that not everyone will experience side effects from paliperidone, and some individuals may have a different experience than those listed here. Additionally, the severity and duration of side effects can vary among individuals.

I apologize for the misunderstanding earlier. Here’s an example of a table that presents both the side effects and popularity of paliperidone:

Side EffectDescriptionPopularity
Weight gainPaliperidone can cause weight gainCommon
SedationPaliperidone can cause sedationCommon
Movement disordersPaliperidone can cause movement disorders such as akathisia, tremors, and dystoniaCommon
Cardiovascular effectsPaliperidone can cause changes in heart rate and blood pressureLess Common
Metabolic effectsPaliperidone can cause changes in blood sugar, cholesterol, and triglyceride levelsLess Common

Note: The popularity column indicates how frequently the side effect occurs in individuals taking paliperidone. “Common” means the side effect occurs in 1-10% of individuals, while “Less Common” means it occurs in less than 1% of individuals.

If you experience any side effects from paliperidone, be sure to discuss them with your healthcare provider. They may be able to adjust your dose or switch you to a different medication to minimize side effects and improve your overall treatment experience.

In conclusion, paliperidone can be an effective treatment option for individuals with schizophrenia and related conditions. However, it’s important to be aware of potential side effects and to work closely with a healthcare provider when taking this medication.


There are various forms of drugs available, such as tablets or liquids, and each may have a separate patient information leaflet (PIL) for different doses. It is important to refer to the PIL for the specific form and dose of the drug that you have been prescribed.

You can search for further information and PILs on websites such as:

  • The British National Formulary (BNF)
  • Electronic medicines compendium (emc)
  • The National Library of Medicine's DailyMed
  • The Food and Drug Administration (FDA) 
  • Different drug forms like tablets or liquids have specific patient information leaflets (PIL) for various doses. Refer to the PIL for your prescribed drug form and dose.

    Search for PILs on websites like:

    France

    • ANSM (Agence nationale de sécurité du médicament et des produits de santé): ansm.sante.fr

    Spain

    • AEMPS (Agencia Española de Medicamentos y Productos Sanitarios): aemps.gob.es

    Germany

    • BfArM (Bundesinstitut für Arzneimittel und Medizinprodukte): bfarm.de

    Italy

    For questions about your medication:

    • Consult your doctor, a healthcare professional, or a pharmacist

    France

    • Contact SOS Médecins: 3624
    • For mental health support, contact SOS Suicide: 01 45 39 40 00

    Belgium (French)

    Switzerland (French)

    • La Main Tendue: 143
    • Website: 143.ch

    Canada (French)

    • Centre de prévention du suicide du Québec: 1 866 APPELLE (1 866 277-3553)
    • Website: cpsquebec.ca

    Spain

    • Contact emergency number: 112
    • For mental health support, contact Teléfono de la Esperanza: 717 003 717

    Germany

    • Contact emergency number: 112
    • For mental health support, contact Telefonseelsorge: 0800 111 0 111 or 0800 111 0 222

    Italy

    • Contact emergency number: 112
    • For mental health support, contact Telefono Amico: 199 284 284

    Netherlands

    • Contact emergency number: 112
    • For mental health support, contact 113 Zelfmoordpreventie: 0800 0113

    Portugal

    • Contact emergency number: 112
    • For mental health support, contact Sos Voz Amiga: 21 354 45 45, 91 280 26 69, or 96 352 46 60

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