What are the long term side effects of quetiapine?

Long-term use of quetiapine may increase the risk of certain side effects or complications. Some of the potential long-term side effects of quetiapine include:

  1. Metabolic changes: Quetiapine can cause metabolic changes, such as weight gain, high blood sugar, and changes in cholesterol levels. These changes may increase the risk of developing diabetes or other health problems.
  2. Movement disorders: Long-term use of quetiapine can increase the risk of developing movement disorders, such as tardive dyskinesia, a condition characterized by involuntary movements of the face, tongue, and limbs.
  3. Cardiovascular effects: Quetiapine can cause changes in heart rate and blood pressure, which may increase the risk of heart attack, stroke, or other cardiovascular problems.
  4. Neurological effects: Long-term use of quetiapine can affect the nervous system and may cause symptoms such as tremors, muscle stiffness, or seizures.
  5. Tolerance and dependence: Long-term use of quetiapine can lead to tolerance, which means that higher doses of the medication may be needed to achieve the same therapeutic effect. It can also lead to dependence, which means that withdrawal symptoms may occur if the medication is stopped abruptly.
  6. Cognitive effects: Long-term use of quetiapine may affect cognitive function, including memory, attention, and decision-making abilities.

It is important to discuss any concerns about long-term side effects of quetiapine with a healthcare provider, who can help determine the most appropriate treatment plan based on individual needs and medical history. Regular monitoring and screening for potential side effects may also be recommended for individuals taking quetiapine for extended periods of time.


There are various forms of drugs available, such as tablets or liquids, and each may have a separate patient information leaflet (PIL) for different doses. It is important to refer to the PIL for the specific form and dose of the drug that you have been prescribed.

You can search for further information and PILs on websites such as: