What are the main side effects of duloxetine?

Duloxetine is a medication used to treat depression, anxiety disorders, and chronic pain. While it can be effective in treating these conditions, it can also come with potential side effects that can impact a person’s quality of life.

In this article, we’ll explore the main side effects of duloxetine in depth, including what they are, how common they are, and how they can be managed.

What is Duloxetine?

Duloxetine is a medication known as a selective serotonin and norepinephrine reuptake inhibitor (SNRI). It works by increasing the levels of certain neurotransmitters in the brain, including serotonin and norepinephrine. This can help alleviate symptoms of depression, anxiety, and chronic pain.

Side Effects of Duloxetine

Like any medication, duloxetine can come with potential side effects. Some of the most common side effects of duloxetine include:

  1. Nausea: Many people experience nausea when taking duloxetine, particularly when first starting the medication. This side effect usually goes away over time as the body becomes accustomed to the medication.
  2. Headache: Some people experience headaches when taking duloxetine. This side effect can usually be managed with over-the-counter pain relievers.
  3. Dry mouth: Duloxetine can cause dry mouth, which can be uncomfortable and increase the risk of dental problems.
  4. Insomnia: Some people experience difficulty sleeping or insomnia when taking duloxetine. This side effect can usually be managed with good sleep hygiene practices, such as avoiding caffeine and electronic devices before bedtime.
  5. Dizziness: Duloxetine can cause dizziness or lightheadedness, particularly when standing up quickly. This side effect can usually be managed by standing up slowly and holding onto something for support.
  6. Constipation: Duloxetine can cause constipation in some people. This side effect can usually be managed with dietary changes, such as increasing fiber intake and drinking more water.
  7. Sweating: Some people experience excessive sweating when taking duloxetine. This side effect can usually be managed with good hygiene practices, such as showering regularly and wearing breathable clothing.
  8. Sexual side effects: Duloxetine can cause sexual side effects in some people, including decreased libido and difficulty achieving orgasm. These side effects can be particularly distressing for some people and may require medication adjustments or other interventions.

Managing Side Effects of Duloxetine

If you are experiencing side effects from duloxetine, it’s important to talk to your healthcare provider. They can provide guidance on how to manage side effects and may adjust your medication dose or switch you to a different medication if necessary.

In addition to medication adjustments, there are several other strategies that can help manage side effects of duloxetine. These include:

  1. Good sleep hygiene: If you are experiencing insomnia or other sleep disturbances, practicing good sleep hygiene can help. This includes avoiding electronic devices before bedtime, creating a relaxing sleep environment, and establishing a consistent sleep schedule.
  2. Dietary changes: If you are experiencing constipation or other gastrointestinal side effects, making dietary changes such as increasing fiber intake and drinking more water can help.
  3. Hygiene practices: If you are experiencing excessive sweating or other hygiene-related side effects, practicing good hygiene habits such as showering regularly and wearing breathable clothing can help.
  4. Therapy: If you are experiencing sexual side effects or other distressing side effects, therapy may be helpful in managing these symptoms and improving overall quality of life.

Conclusion

Duloxetine is a medication commonly used to treat depression, anxiety disorders, and chronic pain. While it can be effective in treating these conditions, it can also come with potential side effects. By understanding the main side effects of duloxetine and how to manage them, you can make informed decisions about your mental health and well-being. If you are experiencing side effects from duloxetine, it’s important to talk to your healthcare provider about the best strategies for managing these symptoms.


There are various forms of drugs available, such as tablets or liquids, and each may have a separate patient information leaflet (PIL) for different doses. It is important to refer to the PIL for the specific form and dose of the drug that you have been prescribed.

You can search for further information and PILs on websites such as:

  • The British National Formulary (BNF)
  • Electronic medicines compendium (emc)
  • The National Library of Medicine's DailyMed
  • The Food and Drug Administration (FDA) 
  • Different drug forms like tablets or liquids have specific patient information leaflets (PIL) for various doses. Refer to the PIL for your prescribed drug form and dose.

    Search for PILs on websites like:

    France

    • ANSM (Agence nationale de sécurité du médicament et des produits de santé): ansm.sante.fr

    Spain

    • AEMPS (Agencia Española de Medicamentos y Productos Sanitarios): aemps.gob.es

    Germany

    • BfArM (Bundesinstitut für Arzneimittel und Medizinprodukte): bfarm.de

    Italy

    For questions about your medication:

    • Consult your doctor, a healthcare professional, or a pharmacist

    France

    • Contact SOS Médecins: 3624
    • For mental health support, contact SOS Suicide: 01 45 39 40 00

    Belgium (French)

    Switzerland (French)

    • La Main Tendue: 143
    • Website: 143.ch

    Canada (French)

    • Centre de prévention du suicide du Québec: 1 866 APPELLE (1 866 277-3553)
    • Website: cpsquebec.ca

    Spain

    • Contact emergency number: 112
    • For mental health support, contact Teléfono de la Esperanza: 717 003 717

    Germany

    • Contact emergency number: 112
    • For mental health support, contact Telefonseelsorge: 0800 111 0 111 or 0800 111 0 222

    Italy

    • Contact emergency number: 112
    • For mental health support, contact Telefono Amico: 199 284 284

    Netherlands

    • Contact emergency number: 112
    • For mental health support, contact 113 Zelfmoordpreventie: 0800 0113

    Portugal

    • Contact emergency number: 112
    • For mental health support, contact Sos Voz Amiga: 21 354 45 45, 91 280 26 69, or 96 352 46 60

Log In

Forgot password?

Forgot password?

Enter your account data and we will send you a link to reset your password.

Your password reset link appears to be invalid or expired.

Log in

Privacy Policy

Add to Collection

No Collections

Here you'll find all collections you've created before.