What is a major side effect of bupropion?

Bupropion is a medication that is used to treat depression, aid in smoking cessation, and potentially promote weight loss or reduce symptoms of ADHD. While it has several benefits, it can also cause side effects, some of which can be serious. In this response, we will explore one of the major side effects of bupropion in detail.

Seizures: One of the major side effects of bupropion is the risk of seizures, particularly at higher doses. Seizures are caused by abnormal electrical activity in the brain, and can range from mild to severe. In rare cases, seizures can lead to serious complications, including brain damage or death.

Risk Factors: The risk of seizures is generally higher in individuals who take high doses of bupropion, have a history of seizures or epilepsy, have had head trauma, or are taking other medications that can lower the seizure threshold. It is important for individuals taking bupropion to discuss their medical history and any other medications they are taking with their doctor or healthcare provider.

Symptoms: Seizures can cause a range of symptoms, including convulsions or shaking, loss of consciousness, confusion, and muscle rigidity. If an individual experiences a seizure while taking bupropion, it is important for them to seek medical attention immediately.

Prevention: To reduce the risk of seizures, it is important for individuals taking bupropion to follow their doctor or healthcare provider’s instructions carefully. This may include starting with a lower dose and gradually increasing it over time, avoiding other medications that can lower the seizure threshold, and monitoring for any signs of a seizure.

Conclusion: While bupropion can be an effective medication for treating depression, aiding in smoking cessation, and potentially promoting weight loss or reducing symptoms of ADHD, it is important for individuals to be aware of the potential side effects, including the risk of seizures. Individuals taking bupropion should discuss any concerns with their doctor or healthcare provider and seek medical attention immediately if they experience any symptoms of a seizure.


There are various forms of drugs available, such as tablets or liquids, and each may have a separate patient information leaflet (PIL) for different doses. It is important to refer to the PIL for the specific form and dose of the drug that you have been prescribed.

You can search for further information and PILs on websites such as:

  • The British National Formulary (BNF)
  • Electronic medicines compendium (emc)
  • The National Library of Medicine's DailyMed
  • The Food and Drug Administration (FDA) 
  • Different drug forms like tablets or liquids have specific patient information leaflets (PIL) for various doses. Refer to the PIL for your prescribed drug form and dose.

    Search for PILs on websites like:

    France

    • ANSM (Agence nationale de sécurité du médicament et des produits de santé): ansm.sante.fr

    Spain

    • AEMPS (Agencia Española de Medicamentos y Productos Sanitarios): aemps.gob.es

    Germany

    • BfArM (Bundesinstitut für Arzneimittel und Medizinprodukte): bfarm.de

    Italy

    For questions about your medication:

    • Consult your doctor, a healthcare professional, or a pharmacist

    France

    • Contact SOS Médecins: 3624
    • For mental health support, contact SOS Suicide: 01 45 39 40 00

    Belgium (French)

    Switzerland (French)

    • La Main Tendue: 143
    • Website: 143.ch

    Canada (French)

    • Centre de prévention du suicide du Québec: 1 866 APPELLE (1 866 277-3553)
    • Website: cpsquebec.ca

    Spain

    • Contact emergency number: 112
    • For mental health support, contact Teléfono de la Esperanza: 717 003 717

    Germany

    • Contact emergency number: 112
    • For mental health support, contact Telefonseelsorge: 0800 111 0 111 or 0800 111 0 222

    Italy

    • Contact emergency number: 112
    • For mental health support, contact Telefono Amico: 199 284 284

    Netherlands

    • Contact emergency number: 112
    • For mental health support, contact 113 Zelfmoordpreventie: 0800 0113

    Portugal

    • Contact emergency number: 112
    • For mental health support, contact Sos Voz Amiga: 21 354 45 45, 91 280 26 69, or 96 352 46 60

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