What is amitriptyline mainly used for?

Amitriptyline is a medication that belongs to the class of drugs known as tricyclic antidepressants. It is primarily used to treat depression, but may also be used to treat other conditions such as chronic pain, migraine headaches, and sleep disorders.

Treatment of Depression:

Amitriptyline is mainly used to treat depression, a mental health disorder that affects millions of people worldwide. Depression is characterized by feelings of sadness, hopelessness, and a lack of interest in activities that were once enjoyable. Amitriptyline works by increasing the levels of certain neurotransmitters, such as serotonin and norepinephrine, in the brain, which helps to improve mood and alleviate symptoms of depression.

Chronic Pain Management:

In addition to treating depression, amitriptyline may also be used to manage chronic pain conditions, such as fibromyalgia and neuropathic pain. Amitriptyline works by altering the way the brain perceives pain signals, which can help reduce pain levels and improve quality of life for those living with chronic pain.

Migraine Headache Treatment:

Amitriptyline may also be used to prevent the onset of migraine headaches. It is believed that amitriptyline works by reducing the frequency and intensity of migraine headaches by altering the levels of certain neurotransmitters in the brain.

Sleep Disorders:

Amitriptyline can also be used to treat sleep disorders such as insomnia. It helps to reduce the time it takes to fall asleep and improve the quality of sleep by increasing the amount of time spent in deep sleep.

It is important to note that amitriptyline should only be taken under the guidance of a healthcare professional, as it can cause a range of side effects, including drowsiness, dry mouth, blurred vision, constipation, and weight gain. It may also cause more serious side effects, such as changes in heart rate or rhythm, seizures, and suicidal thoughts or behaviors, particularly in children, adolescents, and young adults. If you are experiencing any side effects while taking amitriptyline, it is important to talk to your doctor as soon as possible.

There are various forms of drugs available, such as tablets or liquids, and each may have a separate patient information leaflet (PIL) for different doses. It is important to refer to the PIL for the specific form and dose of the drug that you have been prescribed.

You can search for further information and PILs on websites such as:

  • The British National Formulary (BNF)
  • Electronic medicines compendium (emc)
  • The National Library of Medicine's DailyMed
  • The Food and Drug Administration (FDA) 
  • Different drug forms like tablets or liquids have specific patient information leaflets (PIL) for various doses. Refer to the PIL for your prescribed drug form and dose.

    Search for PILs on websites like:


    • ANSM (Agence nationale de sécurité du médicament et des produits de santé): ansm.sante.fr


    • AEMPS (Agencia Española de Medicamentos y Productos Sanitarios): aemps.gob.es


    • BfArM (Bundesinstitut für Arzneimittel und Medizinprodukte): bfarm.de


    For questions about your medication:

    • Consult your doctor, a healthcare professional, or a pharmacist


    • Contact SOS Médecins: 3624
    • For mental health support, contact SOS Suicide: 01 45 39 40 00

    Belgium (French)

    Switzerland (French)

    • La Main Tendue: 143
    • Website: 143.ch

    Canada (French)

    • Centre de prévention du suicide du Québec: 1 866 APPELLE (1 866 277-3553)
    • Website: cpsquebec.ca


    • Contact emergency number: 112
    • For mental health support, contact Teléfono de la Esperanza: 717 003 717


    • Contact emergency number: 112
    • For mental health support, contact Telefonseelsorge: 0800 111 0 111 or 0800 111 0 222


    • Contact emergency number: 112
    • For mental health support, contact Telefono Amico: 199 284 284


    • Contact emergency number: 112
    • For mental health support, contact 113 Zelfmoordpreventie: 0800 0113


    • Contact emergency number: 112
    • For mental health support, contact Sos Voz Amiga: 21 354 45 45, 91 280 26 69, or 96 352 46 60

1 thought on “What is amitriptyline mainly used for?”

Comments are closed.

Log In

Forgot password?

Forgot password?

Enter your account data and we will send you a link to reset your password.

Your password reset link appears to be invalid or expired.

Log in

Privacy Policy

Add to Collection

No Collections

Here you'll find all collections you've created before.