What is the most common side effects of lamotrigine?

Lamotrigine is a medication used to treat epilepsy and bipolar disorder. While it can be effective in treating these conditions, it can also cause side effects. In this response, we will explore the most common side effect of lamotrigine in detail, as well as other potential side effects.

Skin Rash: The most common side effect of lamotrigine is a skin rash, which can occur in up to 10% of individuals taking the medication. The rash can range from mild to severe, and can be a sign of a potentially serious allergic reaction. While most rashes are not serious, it is important for individuals taking lamotrigine to monitor their skin carefully and seek medical attention if they develop a rash or any other symptoms of an allergic reaction, such as difficulty breathing or swelling of the face, tongue, or throat. In some cases, a rash may be a sign of a potentially life-threatening condition called Stevens-Johnson syndrome.

Other Side Effects: In addition to skin rash, lamotrigine can cause a range of other side effects, including headache, dizziness, double vision, nausea, and vomiting. These side effects are usually mild and go away on their own over time. However, if they persist or become severe, it is important for individuals to discuss them with their doctor or healthcare provider.

Less Common Side Effects: While less common, lamotrigine can also cause more serious side effects, such as aseptic meningitis, which is inflammation of the protective membranes around the brain and spinal cord. Symptoms of aseptic meningitis can include headache, fever, stiff neck, and sensitivity to light. Lamotrigine can also increase the risk of suicidal thoughts or behavior, particularly in individuals with a history of depression or bipolar disorder.

Conclusion: Lamotrigine is a medication that can be effective in treating epilepsy and bipolar disorder, but it can also cause side effects. The most common side effect of lamotrigine is a skin rash, which can range from mild to severe and may be a sign of a potentially serious allergic reaction. It is important for individuals taking lamotrigine to monitor their skin carefully and seek medical attention if they develop a rash or any other symptoms of an allergic reaction. Other potential side effects of lamotrigine include headache, dizziness, double vision, nausea, and vomiting. If you are experiencing any side effects or concerns about taking lamotrigine, it is important to discuss them with your doctor or healthcare provider.


There are various forms of drugs available, such as tablets or liquids, and each may have a separate patient information leaflet (PIL) for different doses. It is important to refer to the PIL for the specific form and dose of the drug that you have been prescribed.

You can search for further information and PILs on websites such as:

  • The British National Formulary (BNF)
  • Electronic medicines compendium (emc)
  • The National Library of Medicine's DailyMed
  • The Food and Drug Administration (FDA) 
  • Different drug forms like tablets or liquids have specific patient information leaflets (PIL) for various doses. Refer to the PIL for your prescribed drug form and dose.

    Search for PILs on websites like:

    France

    • ANSM (Agence nationale de sécurité du médicament et des produits de santé): ansm.sante.fr

    Spain

    • AEMPS (Agencia Española de Medicamentos y Productos Sanitarios): aemps.gob.es

    Germany

    • BfArM (Bundesinstitut für Arzneimittel und Medizinprodukte): bfarm.de

    Italy

    For questions about your medication:

    • Consult your doctor, a healthcare professional, or a pharmacist

    France

    • Contact SOS Médecins: 3624
    • For mental health support, contact SOS Suicide: 01 45 39 40 00

    Belgium (French)

    Switzerland (French)

    • La Main Tendue: 143
    • Website: 143.ch

    Canada (French)

    • Centre de prévention du suicide du Québec: 1 866 APPELLE (1 866 277-3553)
    • Website: cpsquebec.ca

    Spain

    • Contact emergency number: 112
    • For mental health support, contact Teléfono de la Esperanza: 717 003 717

    Germany

    • Contact emergency number: 112
    • For mental health support, contact Telefonseelsorge: 0800 111 0 111 or 0800 111 0 222

    Italy

    • Contact emergency number: 112
    • For mental health support, contact Telefono Amico: 199 284 284

    Netherlands

    • Contact emergency number: 112
    • For mental health support, contact 113 Zelfmoordpreventie: 0800 0113

    Portugal

    • Contact emergency number: 112
    • For mental health support, contact Sos Voz Amiga: 21 354 45 45, 91 280 26 69, or 96 352 46 60

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