What should I avoid while taking paroxetine?

Paroxetine is a medication that belongs to the selective serotonin reuptake inhibitor (SSRI) class of antidepressants. It is commonly prescribed to treat various mental health conditions such as depression, anxiety, obsessive-compulsive disorder (OCD), and post-traumatic stress disorder (PTSD). While paroxetine can be an effective treatment option, there are certain things that should be avoided while taking the medication. Here’s what you need to know:

Alcohol

Drinking alcohol while taking paroxetine can increase the risk of side effects such as drowsiness, dizziness, and impaired coordination. It can also worsen symptoms of depression and anxiety. It is best to avoid alcohol while taking paroxetine.

Other Medications

Certain medications can interact with paroxetine and increase the risk of side effects. It is important to inform your healthcare provider of all medications you are taking, including prescription medications, over-the-counter medications, and herbal supplements. Some common medications that can interact with paroxetine include blood thinners, anti-seizure medications, and migraine medications.

Grapefruit Juice

Grapefruit juice can interact with paroxetine and increase the risk of side effects. It is best to avoid grapefruit juice while taking paroxetine.

St. John’s Wort

St. John’s Wort is an herbal supplement that is commonly used to treat depression. However, it can interact with paroxetine and increase the risk of side effects. It is best to avoid St. John’s Wort while taking paroxetine.

Driving and Operating Machinery

Paroxetine can cause drowsiness, dizziness, and impaired coordination, which can affect your ability to drive or operate machinery safely. It is important to avoid driving or operating machinery until you know how paroxetine affects you.

In conclusion, while paroxetine can be an effective treatment option for various mental health conditions, it is important to avoid certain things while taking the medication. It is best to avoid alcohol, certain medications, grapefruit juice, St. John’s Wort, and activities that require alertness until you know how paroxetine affects you. It is important to discuss any questions or concerns regarding paroxetine with your healthcare provider.


There are various forms of drugs available, such as tablets or liquids, and each may have a separate patient information leaflet (PIL) for different doses. It is important to refer to the PIL for the specific form and dose of the drug that you have been prescribed.

You can search for further information and PILs on websites such as: