Can you take BuPROPion and Vraylar together?

When managing complex mental health conditions such as depression or bipolar disorder, healthcare professionals sometimes consider a combination of medications to achieve the best outcome for their patients. Two medications that might come up in these conversations are bupropion (often known by its brand name, Wellbutrin) and cariprazine (known as Vraylar). But can you take bupropion and Vraylar together? Let’s explore what the current understanding and medical guidelines suggest.

Understanding Bupropion and Vraylar

Bupropion is primarily prescribed as an antidepressant and is also used to aid smoking cessation. It functions as a norepinephrine-dopamine reuptake inhibitor (NDRI), which means it increases the levels of the neurotransmitters norepinephrine and dopamine in the brain. This action can help improve mood, concentration, and energy levels.

Vraylar, on the other hand, is an atypical antipsychotic that is used to treat schizophrenia and bipolar disorder. It works by balancing dopamine and serotonin levels to improve thinking, mood, and behavior.

Can You Take Them Together?

In some cases, doctors may prescribe both bupropion and Vraylar to a patient. This might happen when:

  1. Additional Antidepressant Effect is Needed: For individuals with bipolar disorder who are experiencing depressive symptoms, adding bupropion to Vraylar may provide additional antidepressant effects.
  2. Treatment-Resistant Depression: Sometimes, in cases of treatment-resistant depression, a combination of medications is necessary to manage symptoms effectively.
  3. Complementary Mechanisms of Action: Because bupropion and Vraylar work differently in the brain, they can complement each other’s effects.

Considering the Risks

Despite the potential benefits, combining these medications is not without risks. Here are some factors to consider:

  • Drug Interactions: There’s always a risk of drug interactions when taking multiple medications. Each individual reacts differently, and adverse effects can occur.
  • Side Effects: Both medications come with their own set of side effects, and taking them together can increase the likelihood of experiencing these.
  • Bipolar Disorder Concerns: For individuals with bipolar disorder, taking an antidepressant alone can sometimes trigger manic episodes. Therefore, it’s important to have mood-stabilizing medication on board, which is where Vraylar comes in.

Best Practices When Taking Bupropion and Vraylar

  1. Consult Your Healthcare Provider: Never start, stop, or combine medications without the guidance of your healthcare provider.
  2. Monitor Closely: If your doctor prescribes both medications, you’ll need to be monitored closely for any adverse effects or signs of interaction.
  3. Report Any Changes: Keep your healthcare provider informed about any new symptoms or changes in your condition.


While taking bupropion and Vraylar together is possible under certain circumstances, it should only be done under the strict supervision of a healthcare professional. The combination can be beneficial for some patients, but it requires careful consideration of the potential risks and benefits. Always follow your doctor’s advice and report any concerns or side effects you experience.

Remember, medication management is highly individualized, and what works for one person may not work for another. Ongoing communication with your healthcare provider is key to finding the most effective treatment plan for you.

There are various forms of drugs available, such as tablets or liquids, and each may have a separate patient information leaflet (PIL) for different doses. It is important to refer to the PIL for the specific form and dose of the drug that you have been prescribed.

You can search for further information and PILs on websites such as: