Can you take bupropion at night?

Bupropion is typically taken once or twice a day, with or without food. The timing of the dose can depend on the individual’s preference and the specific condition being treated.

While bupropion can be taken at any time of day, it is generally recommended to take it in the morning or early afternoon to minimize the risk of insomnia or sleep disturbances. Taking bupropion too close to bedtime may interfere with sleep and cause difficulty falling or staying asleep.

However, it is important to follow the dosing schedule recommended by your healthcare provider and to take the medication at the same time(s) each day to maintain consistent levels in the body.

If you have concerns about the timing of your bupropion dose or are experiencing sleep disturbances while taking the medication, it is important to discuss this with your healthcare provider. They may be able to adjust the timing of the dose or recommend other strategies to promote healthy sleep habits.


There are various forms of drugs available, such as tablets or liquids, and each may have a separate patient information leaflet (PIL) for different doses. It is important to refer to the PIL for the specific form and dose of the drug that you have been prescribed.

You can search for further information and PILs on websites such as: