Does nortriptyline cause weight gain?

Yes, nortriptyline can cause weight gain in some individuals. Weight gain is a common side effect of many antidepressant medications, including nortriptyline. The exact mechanism by which nortriptyline causes weight gain is not fully understood, but it may be related to changes in appetite, metabolic rate, or hormone levels.

Weight gain associated with nortriptyline use may be gradual and may occur over weeks or months. It may also vary depending on the individual and the dosage of the medication being taken. The risk of weight gain may be higher in individuals who are already overweight or obese, or who have a family history of obesity.

If weight gain is a concern while taking nortriptyline, there are several strategies that may help to manage this side effect, including:

  1. Eating a healthy, balanced diet that is low in calories and high in nutrients.
  2. Exercising regularly, such as with moderate-intensity aerobic exercise for at least 30 minutes per day.
  3. Monitoring weight and body mass index (BMI) regularly, and discussing any changes with a healthcare provider.
  4. Considering alternative medications or treatments, if weight gain is persistent or bothersome.

It is important to discuss any concerns about weight gain or other side effects of nortriptyline with a healthcare provider, who can help determine the most appropriate treatment plan based on individual needs and medical history.

There are various forms of drugs available, such as tablets or liquids, and each may have a separate patient information leaflet (PIL) for different doses. It is important to refer to the PIL for the specific form and dose of the drug that you have been prescribed.

You can search for further information and PILs on websites such as:

  • The British National Formulary (BNF)
  • Electronic medicines compendium (emc)
  • The National Library of Medicine's DailyMed
  • The Food and Drug Administration (FDA) 
  • Different drug forms like tablets or liquids have specific patient information leaflets (PIL) for various doses. Refer to the PIL for your prescribed drug form and dose.

    Search for PILs on websites like:


    • ANSM (Agence nationale de sécurité du médicament et des produits de santé):


    • AEMPS (Agencia Española de Medicamentos y Productos Sanitarios):


    • BfArM (Bundesinstitut für Arzneimittel und Medizinprodukte):


    For questions about your medication:

    • Consult your doctor, a healthcare professional, or a pharmacist


    • Contact SOS Médecins: 3624
    • For mental health support, contact SOS Suicide: 01 45 39 40 00

    Belgium (French)

    Switzerland (French)

    • La Main Tendue: 143
    • Website:

    Canada (French)

    • Centre de prévention du suicide du Québec: 1 866 APPELLE (1 866 277-3553)
    • Website:


    • Contact emergency number: 112
    • For mental health support, contact Teléfono de la Esperanza: 717 003 717


    • Contact emergency number: 112
    • For mental health support, contact Telefonseelsorge: 0800 111 0 111 or 0800 111 0 222


    • Contact emergency number: 112
    • For mental health support, contact Telefono Amico: 199 284 284


    • Contact emergency number: 112
    • For mental health support, contact 113 Zelfmoordpreventie: 0800 0113


    • Contact emergency number: 112
    • For mental health support, contact Sos Voz Amiga: 21 354 45 45, 91 280 26 69, or 96 352 46 60

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