How quickly does sertraline work?

Sertraline is a medication that is commonly prescribed for the treatment of depression, anxiety disorders, OCD, PTSD, and PMDD. While sertraline can be an effective treatment for these conditions, it may take several weeks before the full effects of the medication are felt.

In general, it may take 4 to 6 weeks for sertraline to start working and for individuals to notice an improvement in their symptoms. However, this timeline can vary depending on the specific condition being treated, the severity of symptoms, and individual factors such as genetics and response to medication.

It is important to keep in mind that sertraline may not work for everyone who takes it. Some individuals may require a higher dose or a different medication to effectively manage their symptoms.

If you are taking sertraline for depression or another mood disorder, it is important to continue taking the medication as prescribed, even if you do not notice an immediate improvement in your symptoms. Stopping sertraline abruptly can cause withdrawal symptoms and may not effectively treat your underlying condition.

In conclusion, sertraline may take several weeks to start working and for individuals to notice an improvement in their symptoms. It is important to work closely with your doctor to determine the best treatment plan for your unique needs and to continue taking the medication as prescribed, even if you do not notice an immediate improvement in your symptoms.


There are various forms of drugs available, such as tablets or liquids, and each may have a separate patient information leaflet (PIL) for different doses. It is important to refer to the PIL for the specific form and dose of the drug that you have been prescribed.

You can search for further information and PILs on websites such as: