Is agomelatine a SSRI?

Agomelatine is not a selective serotonin reuptake inhibitor (SSRI), although it does have an effect on serotonin activity in the brain. Agomelatine is a unique antidepressant that works by modulating the activity of both melatonin and serotonin receptors in the brain.

Unlike SSRIs, which work by selectively blocking the reuptake of serotonin in the brain, agomelatine acts as both an agonist at melatonin receptors and an antagonist at serotonin receptors. This means that it not only increases the activity of melatonin, a hormone that regulates sleep-wake cycles, but also modulates the activity of serotonin, a neurotransmitter that is involved in mood regulation.

While agomelatine does not work in the same way as SSRIs, it can be effective in treating depression and anxiety in some individuals. It is important to note, however, that not all individuals with depression or anxiety will respond to agomelatine, and it may not be the best choice of medication for everyone. The decision to use agomelatine or any other medication should be made in consultation with a healthcare provider, who can help determine the most appropriate treatment plan based on individual needs and medical history.

There are various forms of drugs available, such as tablets or liquids, and each may have a separate patient information leaflet (PIL) for different doses. It is important to refer to the PIL for the specific form and dose of the drug that you have been prescribed.

You can search for further information and PILs on websites such as: