Does agomelatine cause weight gain?

Weight gain is a possible side effect of agomelatine, although it is not a common one. Clinical studies have shown that weight gain occurs in less than 1% of individuals taking agomelatine, and the amount of weight gain is typically modest.

The exact mechanism by which agomelatine may cause weight gain is not fully understood. However, it is thought to be related to changes in appetite or metabolism that can occur as a side effect of the medication.

It is important to note that not all individuals who take agomelatine will experience weight gain, and the risk of weight gain may be influenced by other factors, such as diet, exercise habits, and genetics. If an individual experiences weight gain or any other concerning changes in weight while taking agomelatine, they should speak with their healthcare provider. The healthcare provider may adjust the dosage or consider switching to a different medication to help manage side effects.


There are various forms of drugs available, such as tablets or liquids, and each may have a separate patient information leaflet (PIL) for different doses. It is important to refer to the PIL for the specific form and dose of the drug that you have been prescribed.

You can search for further information and PILs on websites such as:

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