Is duloxetine risky?

Like all medications, duloxetine (brand name Cymbalta) carries some risks. Duloxetine is primarily used to treat depression, anxiety, and other mood disorders. While it can be an effective treatment for some individuals, there are some potential risks associated with its use.

One of the main risks of duloxetine is the potential for side effects. Common side effects of duloxetine can include nausea, dry mouth, constipation, and decreased appetite. Other potential side effects can include dizziness, headache, and sexual dysfunction. In rare cases, duloxetine can cause more serious side effects, such as liver damage, bleeding, or a decrease in sodium levels in the blood.

Another risk of duloxetine is the potential for drug interactions. Duloxetine can interact with other medications, including over-the-counter medications and herbal supplements. It’s important for individuals taking duloxetine to discuss their full medication history with their doctor to avoid potentially harmful interactions.

Finally, there is some evidence to suggest that duloxetine and other antidepressants may increase the risk of suicidal thoughts and behaviors, particularly in young people. This risk is generally considered to be low, but it’s important for individuals taking duloxetine to be aware of the potential risk and to seek medical attention if they experience any unusual changes in mood or behavior.

Overall, while duloxetine can be an effective treatment for depression, anxiety, and other mood disorders, it’s important for individuals to discuss the potential risks and benefits with their doctor and to carefully monitor for any side effects or changes in mood or behavior.


There are various forms of drugs available, such as tablets or liquids, and each may have a separate patient information leaflet (PIL) for different doses. It is important to refer to the PIL for the specific form and dose of the drug that you have been prescribed.

You can search for further information and PILs on websites such as: