Is it OK to take mirtazapine every night?

Mirtazapine is typically prescribed to be taken once daily at bedtime, as it can cause drowsiness and has a sedative effect. It is important to follow the dosing instructions provided by your healthcare provider and not to exceed the recommended dose.

Taking mirtazapine every night as prescribed by a healthcare professional is generally considered safe for most people. However, like all medications, it can have potential side effects, and it is important to discuss any concerns or questions you have about mirtazapine with your healthcare provider.

Dosing instructions for mirtazapine

The dosing instructions for mirtazapine are as follows:

  • Mirtazapine is typically taken once daily at bedtime.
  • The starting dose is usually 15 mg per day, and the maximum recommended dose is 45 mg per day.
  • Mirtazapine can be taken with or without food.
  • It may take several weeks for the full therapeutic effects of mirtazapine to be felt.
  • It is important not to abruptly stop taking mirtazapine, as this can cause withdrawal symptoms. It is recommended to work with your healthcare provider to gradually taper off the medication if you decide to stop taking it.

It is important to note that the dosing instructions for mirtazapine can vary depending on the individual’s condition and other factors, so it is important to follow the specific instructions provided by your healthcare provider.


There are various forms of drugs available, such as tablets or liquids, and each may have a separate patient information leaflet (PIL) for different doses. It is important to refer to the PIL for the specific form and dose of the drug that you have been prescribed.

You can search for further information and PILs on websites such as:

  • The British National Formulary (BNF)
  • Electronic medicines compendium (emc)
  • The National Library of Medicine's DailyMed
  • The Food and Drug Administration (FDA) 
  • Different drug forms like tablets or liquids have specific patient information leaflets (PIL) for various doses. Refer to the PIL for your prescribed drug form and dose.

    Search for PILs on websites like:

    France

    • ANSM (Agence nationale de sécurité du médicament et des produits de santé): ansm.sante.fr

    Spain

    • AEMPS (Agencia Española de Medicamentos y Productos Sanitarios): aemps.gob.es

    Germany

    • BfArM (Bundesinstitut für Arzneimittel und Medizinprodukte): bfarm.de

    Italy

    For questions about your medication:

    • Consult your doctor, a healthcare professional, or a pharmacist

    France

    • Contact SOS Médecins: 3624
    • For mental health support, contact SOS Suicide: 01 45 39 40 00

    Belgium (French)

    Switzerland (French)

    • La Main Tendue: 143
    • Website: 143.ch

    Canada (French)

    • Centre de prévention du suicide du Québec: 1 866 APPELLE (1 866 277-3553)
    • Website: cpsquebec.ca

    Spain

    • Contact emergency number: 112
    • For mental health support, contact Teléfono de la Esperanza: 717 003 717

    Germany

    • Contact emergency number: 112
    • For mental health support, contact Telefonseelsorge: 0800 111 0 111 or 0800 111 0 222

    Italy

    • Contact emergency number: 112
    • For mental health support, contact Telefono Amico: 199 284 284

    Netherlands

    • Contact emergency number: 112
    • For mental health support, contact 113 Zelfmoordpreventie: 0800 0113

    Portugal

    • Contact emergency number: 112
    • For mental health support, contact Sos Voz Amiga: 21 354 45 45, 91 280 26 69, or 96 352 46 60

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