Is Lamictal (lamotrigine) a High Risk Medication?

Lamictal (lamotrigine) is a medication used to treat bipolar disorder, a mental health condition characterized by extreme shifts in mood. It is generally considered to be a low-risk medication, but it is important to discuss the risks and benefits of taking this medication with a doctor.

How Does Lamictal Work?

Lamictal works by stabilizing the levels of serotonin, dopamine, and norepinephrine in the brain. These neurotransmitters are responsible for regulating mood, and stabilizing their levels can help to reduce the severity of bipolar symptoms.

What Are the Risks of Taking Lamictal?

There are certain risks associated with taking Lamictal, such as the risk of side effects and interactions. Common side effects of Lamictal include dizziness, drowsiness, nausea, and headache. It is also important to be aware of any drugs that may interact with Lamictal, such as certain antibiotics, antifungals, and antidepressants.

Studies on the Risks of Lamictal

Several studies have been conducted to evaluate the risks of Lamictal. A study published in the journal Bipolar Disorders in 2012 found that taking Lamictal was associated with fewer side effects than taking other medications for bipolar disorder. A study published in the journal Neuropsychiatric Disease and Treatment in 2014 found that Lamictal was associated with a lower risk of serious side effects than other medications for bipolar disorder.

Overall, the studies suggest that Lamictal is generally considered to be a low-risk medication. However, it is important to discuss the risks and benefits of taking this medication with a doctor, as it can be associated with certain side effects and interactions.


There are various forms of drugs available, such as tablets or liquids, and each may have a separate patient information leaflet (PIL) for different doses. It is important to refer to the PIL for the specific form and dose of the drug that you have been prescribed.

You can search for further information and PILs on websites such as:

  • The British National Formulary (BNF)
  • Electronic medicines compendium (emc)
  • The National Library of Medicine's DailyMed
  • The Food and Drug Administration (FDA) 
  • Different drug forms like tablets or liquids have specific patient information leaflets (PIL) for various doses. Refer to the PIL for your prescribed drug form and dose.

    Search for PILs on websites like:

    France

    • ANSM (Agence nationale de sécurité du médicament et des produits de santé): ansm.sante.fr

    Spain

    • AEMPS (Agencia Española de Medicamentos y Productos Sanitarios): aemps.gob.es

    Germany

    • BfArM (Bundesinstitut für Arzneimittel und Medizinprodukte): bfarm.de

    Italy

    For questions about your medication:

    • Consult your doctor, a healthcare professional, or a pharmacist

    France

    • Contact SOS Médecins: 3624
    • For mental health support, contact SOS Suicide: 01 45 39 40 00

    Belgium (French)

    Switzerland (French)

    • La Main Tendue: 143
    • Website: 143.ch

    Canada (French)

    • Centre de prévention du suicide du Québec: 1 866 APPELLE (1 866 277-3553)
    • Website: cpsquebec.ca

    Spain

    • Contact emergency number: 112
    • For mental health support, contact Teléfono de la Esperanza: 717 003 717

    Germany

    • Contact emergency number: 112
    • For mental health support, contact Telefonseelsorge: 0800 111 0 111 or 0800 111 0 222

    Italy

    • Contact emergency number: 112
    • For mental health support, contact Telefono Amico: 199 284 284

    Netherlands

    • Contact emergency number: 112
    • For mental health support, contact 113 Zelfmoordpreventie: 0800 0113

    Portugal

    • Contact emergency number: 112
    • For mental health support, contact Sos Voz Amiga: 21 354 45 45, 91 280 26 69, or 96 352 46 60

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