Pregabalin Interactions: What You Need to Know

Pregabalin can interact with several medications and substances, which can increase the risk of side effects or reduce the effectiveness of pregabalin. It’s important to inform your healthcare provider of all medications, supplements, and herbal products you are taking before starting pregabalin. Here are some examples of pregabalin interactions:

  1. Opioids: Pregabalin can increase the risk of respiratory depression when taken with opioids, such as codeine, fentanyl, and oxycodone. Your healthcare provider may need to adjust your dose or monitor you closely if you are taking these medications together.
  2. Sedatives and hypnotics: Pregabalin can cause drowsiness and dizziness, and taking it with other medications that have similar effects, such as benzodiazepines and zolpidem, can increase the risk of falls and accidents.
  3. Alcohol: Drinking alcohol while taking pregabalin can increase the risk of drowsiness, dizziness, and impaired coordination.
  4. Antihypertensive medications: Pregabalin can cause peripheral edema (swelling in the legs and feet), and taking it with medications that also have this side effect, such as calcium channel blockers and diuretics, can increase the risk of edema.
  5. NSAIDs: Nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen and naproxen, can increase the risk of kidney damage when taken with pregabalin. Your healthcare provider may need to monitor your kidney function if you are taking these medications together.
  6. Cimetidine: Cimetidine, a medication used to treat stomach ulcers, can increase the exposure of pregabalin in the body, which can increase the risk of side effects.
  7. Thiazolidinediones: Thiazolidinediones, a class of medications used to treat diabetes, can increase the risk of edema when taken with pregabalin.

It’s important to follow your healthcare provider’s instructions and inform them of any new medications or supplements you plan to take while on pregabalin. They can help monitor for potential interactions and adjust your treatment plan as needed.


There are various forms of drugs available, such as tablets or liquids, and each may have a separate patient information leaflet (PIL) for different doses. It is important to refer to the PIL for the specific form and dose of the drug that you have been prescribed.

You can search for further information and PILs on websites such as:

  • The British National Formulary (BNF)
  • Electronic medicines compendium (emc)
  • The National Library of Medicine's DailyMed
  • The Food and Drug Administration (FDA) 
  • Different drug forms like tablets or liquids have specific patient information leaflets (PIL) for various doses. Refer to the PIL for your prescribed drug form and dose.

    Search for PILs on websites like:

    France

    • ANSM (Agence nationale de sécurité du médicament et des produits de santé): ansm.sante.fr

    Spain

    • AEMPS (Agencia Española de Medicamentos y Productos Sanitarios): aemps.gob.es

    Germany

    • BfArM (Bundesinstitut für Arzneimittel und Medizinprodukte): bfarm.de

    Italy

    For questions about your medication:

    • Consult your doctor, a healthcare professional, or a pharmacist

    France

    • Contact SOS Médecins: 3624
    • For mental health support, contact SOS Suicide: 01 45 39 40 00

    Belgium (French)

    Switzerland (French)

    • La Main Tendue: 143
    • Website: 143.ch

    Canada (French)

    • Centre de prévention du suicide du Québec: 1 866 APPELLE (1 866 277-3553)
    • Website: cpsquebec.ca

    Spain

    • Contact emergency number: 112
    • For mental health support, contact Teléfono de la Esperanza: 717 003 717

    Germany

    • Contact emergency number: 112
    • For mental health support, contact Telefonseelsorge: 0800 111 0 111 or 0800 111 0 222

    Italy

    • Contact emergency number: 112
    • For mental health support, contact Telefono Amico: 199 284 284

    Netherlands

    • Contact emergency number: 112
    • For mental health support, contact 113 Zelfmoordpreventie: 0800 0113

    Portugal

    • Contact emergency number: 112
    • For mental health support, contact Sos Voz Amiga: 21 354 45 45, 91 280 26 69, or 96 352 46 60

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