Trintellix and Wellbutrin: Combo, Reviews, Interactions & Problems

Depression is a complex mental health disorder that presents a significant burden to individuals and society at large. As we strive to understand and manage this condition, a variety of medication options have become available. Two such medicines, Trintellix (vortioxetine) and Wellbutrin (bupropion), have been widely used in the management of depression.

In recent times, there has been growing interest in the use of a Trintellix and Wellbutrin combo for treating depression. In this article, we delve into the specifics of these two drugs, their interactions, and highlight the experiences of individuals who have used both in their treatment regimen.

Understanding Trintellix and Wellbutrin

Trintellix and Wellbutrin are two different types of antidepressants. Trintellix, known generically as vortioxetine, is a selective serotonin reuptake inhibitor (SSRI) that works by increasing the levels of serotonin, a neurotransmitter associated with mood regulation, in the brain.

On the other hand, Wellbutrin, or bupropion, is a norepinephrine-dopamine reuptake inhibitor (NDRI). Instead of primarily focusing on serotonin, it works by increasing the levels of norepinephrine and dopamine, two other neurotransmitters that play a role in mood.

While both are used in the treatment of depression, they have different mechanisms of action, and thus, they can affect individuals differently.

Can You Take Trintellix and Wellbutrin Together?

One question that often arises is whether Trintellix and Wellbutrin can be taken together. In the realm of psychiatry, it is not uncommon for healthcare providers to prescribe more than one medication to treat a condition, especially if the patient has not responded adequately to a single medication, a practice known as augmentation strategy or combination therapy.

However, the decision to take Trintellix and Wellbutrin together should always be made in consultation with a healthcare provider. This is because combining medications can increase the risk of potential side effects and interactions.

Trintellix and Wellbutrin Interactions

Given that Trintellix and Wellbutrin act on different neurotransmitters, one might wonder about the possible interaction between Trintellix and Wellbutrin.

While there is not a significant drug interaction recognized between the two, it is important to note that each medication has its set of potential side effects and risks. Combining these two may increase the likelihood of experiencing these side effects, which can range from mild (such as dry mouth or constipation) to more severe ones (like suicidal thoughts or serotonin syndrome).

It is worth noting that, even though Trintellix and Wellbutrin are not chemically related, they are similar in that they are both used to treat depression and may have similar side effects.

Experiences with Trintellix and Wellbutrin Combo

In the era of internet and social media, it’s become easier for individuals to share their experiences with medications. One platform where many have shared their experiences with the Trintellix and Wellbutrin combo is Reddit.

Many users on the platform have reported positive outcomes when using the combination, with some suggesting that it helped manage their depression symptoms when other treatments didn’t work. Others reported that it helped address specific issues, such as anxiety.

However, it’s also important to note that some users reported encountering problems with the Trintellix and Wellbutrin combo. Some experienced an increase in side effects or found the combination ineffective.

These personal experiences underline the fact that the effectiveness and tolerability of medications can vary greatly from person to person. What works for one individual may not work for another, and what one person tolerates well, another might not.

Trintellix, Wellbutrin, and Other Medications

In some cases, healthcare providers may consider adding another medication to the Trintellix and Wellbutrin combo. For example, some people might be prescribed Buspar (buspirone), an anti-anxiety medication, in addition to Trintellix and Wellbutrin, especially if anxiety is a prominent symptom of their depression.

As with any medication regimen, the addition of a third medication increases the complexity and potential for side effects and interactions. Therefore, this approach should always be under the guidance and supervision of a healthcare provider.


The use of a Trintellix and Wellbutrin combo is a topic that has generated significant interest, particularly among those dealing with depression. While the combination can be effective for some, it is not without potential problems and risks. Therefore, anyone considering this combination should always consult with a healthcare provider to ensure that it is an appropriate and safe option for their particular situation.

It’s important to remember that mental health treatment is a very personal journey, and what works well for one person may not work as well for another.

The Trintellix and Wellbutrin combo, like all treatment options, has potential benefits and risks. It can be an effective solution for some, especially for those who haven’t found success with other treatment options. However, due to potential interactions and side effects, it’s important that this combination is always taken under the supervision of a healthcare provider.

As we move forward, it’s clear that the dialogue about depression treatments is evolving. Online platforms like Reddit are providing spaces for people to share their experiences with different treatment regimens, including the Trintellix and Wellbutrin combo. This shared knowledge can be extremely valuable in helping individuals make informed decisions about their health.

However, while these personal reviews can provide insights, they should never replace professional medical advice. If you’re considering the Trintellix and Wellbutrin combo, or any other treatment for depression, always consult with your healthcare provider first. They can provide a comprehensive assessment of your unique situation and guide you towards the most effective and safest treatment options.

In conclusion, treating depression is a complex process that often involves trying different medications or combinations. The Trintellix and Wellbutrin combo is one such option that has shown promise for some individuals. As we continue to learn more about the intricacies of depression and the brain, we can look forward to the development of even more effective and personalized treatments.

There are various forms of drugs available, such as tablets or liquids, and each may have a separate patient information leaflet (PIL) for different doses. It is important to refer to the PIL for the specific form and dose of the drug that you have been prescribed.

You can search for further information and PILs on websites such as: