Vortioxetine: A Closer Look at the Innovative Antidepressant Trintellix

Vortioxetine, marketed under the brand name Trintellix (formerly known as Brintellix), is a relatively new antidepressant medication that has been gaining attention for its unique mechanism of action and potential benefits. In this blog post, we will explore vortioxetine’s properties, the conditions it is used to treat, and the potential advantages it offers over other antidepressants on the market.

What is Vortioxetine?

Vortioxetine is a selective serotonin reuptake inhibitor (SSRI) and serotonin modulator that was approved by the FDA in 2013. Its unique mechanism of action involves not only the inhibition of serotonin reuptake but also the modulation of various serotonin receptors, which are believed to contribute to its antidepressant effects.

Conditions Treated by Vortioxetine

Vortioxetine is primarily prescribed for the treatment of major depressive disorder (MDD) in adults. However, some studies have also suggested its potential use in treating anxiety disorders, although further research is needed to confirm its efficacy in these conditions.

Potential Benefits of Vortioxetine

  1. Unique mechanism of action: The dual mechanism of action of vortioxetine, involving both the inhibition of serotonin reuptake and the modulation of serotonin receptors, sets it apart from traditional SSRIs. This unique action may provide additional benefits in terms of mood regulation and symptom relief for some patients.
  2. Cognitive enhancement: Some studies have suggested that vortioxetine may have positive effects on cognitive function, improving attention, memory, and executive functioning in patients with major depressive disorder. This potential cognitive enhancement could be particularly beneficial for those who experience cognitive deficits as part of their depressive symptoms.
  3. Tolerability: In clinical trials, vortioxetine has generally been well-tolerated, with a side effect profile similar to other SSRIs. Some patients may experience fewer or less severe side effects with vortioxetine compared to other antidepressants.
  4. Potential for reduced sexual side effects: Sexual dysfunction is a common side effect of many antidepressants, particularly SSRIs. Some evidence suggests that vortioxetine may be associated with a lower risk of sexual side effects compared to other SSRIs, although individual experiences may vary.

Considerations and Potential Drawbacks

While vortioxetine offers several potential advantages, there are some factors to consider:

  1. Cost: As a brand name medication, vortioxetine may be more expensive than generic alternatives. Insurance coverage and affordability may be factors to consider when choosing an antidepressant.
  2. Individual response: As with any medication, individual responses to vortioxetine may vary. Some patients may not achieve the desired therapeutic effects or may experience side effects. It is essential to work closely with a healthcare provider to monitor symptoms and adjust the treatment plan as needed.


Vortioxetine is a promising antidepressant medication with a unique mechanism of action that sets it apart from traditional SSRIs. Its potential cognitive enhancement and favorable side effect profile make it an attractive option for those seeking treatment for major depressive disorder. However, it’s crucial to consult with a healthcare professional before making any changes to your medication regimen to determine if vortioxetine is the right choice for you.

There are various forms of drugs available, such as tablets or liquids, and each may have a separate patient information leaflet (PIL) for different doses. It is important to refer to the PIL for the specific form and dose of the drug that you have been prescribed.

You can search for further information and PILs on websites such as:

  • The British National Formulary (BNF)
  • Electronic medicines compendium (emc)
  • The National Library of Medicine's DailyMed
  • The Food and Drug Administration (FDA) 
  • Different drug forms like tablets or liquids have specific patient information leaflets (PIL) for various doses. Refer to the PIL for your prescribed drug form and dose.

    Search for PILs on websites like:


    • ANSM (Agence nationale de sécurité du médicament et des produits de santé): ansm.sante.fr


    • AEMPS (Agencia Española de Medicamentos y Productos Sanitarios): aemps.gob.es


    • BfArM (Bundesinstitut für Arzneimittel und Medizinprodukte): bfarm.de


    For questions about your medication:

    • Consult your doctor, a healthcare professional, or a pharmacist


    • Contact SOS Médecins: 3624
    • For mental health support, contact SOS Suicide: 01 45 39 40 00

    Belgium (French)

    Switzerland (French)

    • La Main Tendue: 143
    • Website: 143.ch

    Canada (French)

    • Centre de prévention du suicide du Québec: 1 866 APPELLE (1 866 277-3553)
    • Website: cpsquebec.ca


    • Contact emergency number: 112
    • For mental health support, contact Teléfono de la Esperanza: 717 003 717


    • Contact emergency number: 112
    • For mental health support, contact Telefonseelsorge: 0800 111 0 111 or 0800 111 0 222


    • Contact emergency number: 112
    • For mental health support, contact Telefono Amico: 199 284 284


    • Contact emergency number: 112
    • For mental health support, contact 113 Zelfmoordpreventie: 0800 0113


    • Contact emergency number: 112
    • For mental health support, contact Sos Voz Amiga: 21 354 45 45, 91 280 26 69, or 96 352 46 60

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