What are the advantages of agomelatine?

The advantages of agomelatine include:

  1. Unique mechanism of action: Agomelatine is a unique antidepressant that works by modulating the activity of both melatonin and serotonin receptors in the brain. This dual mechanism of action may provide advantages over other antidepressant medications, particularly for individuals with disrupted sleep-wake cycles or other circadian rhythm disturbances.
  2. Good tolerability: Agomelatine is generally well-tolerated by most individuals, with a low incidence of side effects compared to some other antidepressant medications. It does not typically cause sexual dysfunction, weight gain, or cognitive impairment, which are common side effects of many other antidepressant medications.
  3. Improves sleep quality: Agomelatine has been shown to improve sleep quality and reduce sleep disturbances in individuals with depression or anxiety. This may be particularly beneficial for individuals who experience disrupted sleep-wake cycles or other sleep-related symptoms.
  4. Effective in treating depression: Clinical studies have shown that agomelatine can be effective in reducing symptoms of depression, including low mood, loss of interest in activities, and disrupted sleep patterns. It may be particularly effective for individuals with atypical depression or other forms of depression that are not well-treated by other antidepressant medications.
  5. Rapid onset of action: Agomelatine has a rapid onset of action, with some individuals experiencing improvements in mood and sleep within the first week of treatment.

It is important to note that not all individuals with depression or anxiety will respond to agomelatine, and it may not be the best choice of medication for everyone. The decision to use agomelatine or any other medication should be made in consultation with a healthcare provider, who can help determine the most appropriate treatment plan based on individual needs and medical history.

There are various forms of drugs available, such as tablets or liquids, and each may have a separate patient information leaflet (PIL) for different doses. It is important to refer to the PIL for the specific form and dose of the drug that you have been prescribed.

You can search for further information and PILs on websites such as:

  • The British National Formulary (BNF)
  • Electronic medicines compendium (emc)
  • The National Library of Medicine's DailyMed
  • The Food and Drug Administration (FDA) 
  • Different drug forms like tablets or liquids have specific patient information leaflets (PIL) for various doses. Refer to the PIL for your prescribed drug form and dose.

    Search for PILs on websites like:


    • ANSM (Agence nationale de sécurité du médicament et des produits de santé): ansm.sante.fr


    • AEMPS (Agencia Española de Medicamentos y Productos Sanitarios): aemps.gob.es


    • BfArM (Bundesinstitut für Arzneimittel und Medizinprodukte): bfarm.de


    For questions about your medication:

    • Consult your doctor, a healthcare professional, or a pharmacist


    • Contact SOS Médecins: 3624
    • For mental health support, contact SOS Suicide: 01 45 39 40 00

    Belgium (French)

    Switzerland (French)

    • La Main Tendue: 143
    • Website: 143.ch

    Canada (French)

    • Centre de prévention du suicide du Québec: 1 866 APPELLE (1 866 277-3553)
    • Website: cpsquebec.ca


    • Contact emergency number: 112
    • For mental health support, contact Teléfono de la Esperanza: 717 003 717


    • Contact emergency number: 112
    • For mental health support, contact Telefonseelsorge: 0800 111 0 111 or 0800 111 0 222


    • Contact emergency number: 112
    • For mental health support, contact Telefono Amico: 199 284 284


    • Contact emergency number: 112
    • For mental health support, contact 113 Zelfmoordpreventie: 0800 0113


    • Contact emergency number: 112
    • For mental health support, contact Sos Voz Amiga: 21 354 45 45, 91 280 26 69, or 96 352 46 60

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