Is agomelatine the same as melatonin?

Agomelatine is not the same as melatonin, although it does have an effect on melatonin activity in the brain. Melatonin is a hormone that is involved in regulating sleep-wake cycles, while agomelatine is an antidepressant medication that works by modulating the activity of both melatonin and serotonin receptors in the brain.

Agomelatine is a synthetic compound that is structurally similar to melatonin, but it has different pharmacological properties. It acts as both an agonist at melatonin receptors and an antagonist at serotonin receptors, which may contribute to its antidepressant effects.

While both melatonin and agomelatine may have some effects on sleep and mood, they are not interchangeable and should not be used interchangeably without the guidance of a healthcare provider. It is important to discuss potential treatment options with a healthcare provider, who can help determine the most appropriate course of action based on individual needs and medical history.


There are various forms of drugs available, such as tablets or liquids, and each may have a separate patient information leaflet (PIL) for different doses. It is important to refer to the PIL for the specific form and dose of the drug that you have been prescribed.

You can search for further information and PILs on websites such as:

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