What are the contraindications for Benperidol?


Benperidol is contraindicated in patients with known hypersensitivity to the drug or any components of its formulation. Reactions may include rash, itching, swelling, and bronchospasm.

Parkinson’s disease

Benperidol can worsen symptoms of Parkinson’s disease due to its blockade of dopamine receptors. It is therefore contraindicated in patients with Parkinson’s disease.


Benperidol may worsen symptoms of depression and increase the risk of suicidal thoughts and behaviors. It should not be used in patients with severe depression or suicidal ideation.

Cardiovascular disease

Due its potential to prolong the QT interval, benperidol is contraindicated in patients with a history of cardiac arrhythmias, congestive heart failure, or recent myocardial infarction. It can also cause orthostatic hypotension, so should be avoided in patients with uncontrolled hypertension.


Benperidol lowers the seizure threshold and should not be used in patients with epilepsy or a history of seizures.


In patients with pheochromocytoma, benperidol may lead to a hypertensive crisis due to release of catecholamines. It is therefore contraindicated in these patients.

Prostatic hyperplasia

Benperidol has anticholinergic effects and can worsen symptoms of prostatic hyperplasia like urinary retention. It should be avoided in patients with severe prostatic hypertrophy.


In elderly patients with dementia, benperidol confers an increased risk of mortality, cerebrovascular events, and parkinsonism. Due to its significant safety risks, benperidol is contraindicated for behavioral problems in elderly dementia patients.

Hepatic impairment

Due to extensive metabolism of benperidol by the liver, reduced doses or dosage adjustments are recommended in patients with hepatic impairment. However, in severe liver disease the risks may outweigh potential benefits, so use is contraindicated.

Narrow-angle glaucoma

Benperidol can cause pupillary dilatation which may precipitate an attack of narrow-angle glaucoma. It is therefore contraindicated in patients with narrow angle glaucoma.

In summary, benperidol has many contraindications due to its risk of adverse effects in certain susceptible patient populations or disease states. Caution must be exercised if benperidol is used, and in many cases safer alternative treatments may be preferred, especially given the availability of newer atypical antipsychotics with fewer contraindications and side effects.

There are various forms of drugs available, such as tablets or liquids, and each may have a separate patient information leaflet (PIL) for different doses. It is important to refer to the PIL for the specific form and dose of the drug that you have been prescribed.

You can search for further information and PILs on websites such as:

  • The British National Formulary (BNF)
  • Electronic medicines compendium (emc)
  • The National Library of Medicine's DailyMed
  • The Food and Drug Administration (FDA) 
  • Different drug forms like tablets or liquids have specific patient information leaflets (PIL) for various doses. Refer to the PIL for your prescribed drug form and dose.

    Search for PILs on websites like:


    • ANSM (Agence nationale de sécurité du médicament et des produits de santé): ansm.sante.fr


    • AEMPS (Agencia Española de Medicamentos y Productos Sanitarios): aemps.gob.es


    • BfArM (Bundesinstitut für Arzneimittel und Medizinprodukte): bfarm.de


    For questions about your medication:

    • Consult your doctor, a healthcare professional, or a pharmacist


    • Contact SOS Médecins: 3624
    • For mental health support, contact SOS Suicide: 01 45 39 40 00

    Belgium (French)

    Switzerland (French)

    • La Main Tendue: 143
    • Website: 143.ch

    Canada (French)

    • Centre de prévention du suicide du Québec: 1 866 APPELLE (1 866 277-3553)
    • Website: cpsquebec.ca


    • Contact emergency number: 112
    • For mental health support, contact Teléfono de la Esperanza: 717 003 717


    • Contact emergency number: 112
    • For mental health support, contact Telefonseelsorge: 0800 111 0 111 or 0800 111 0 222


    • Contact emergency number: 112
    • For mental health support, contact Telefono Amico: 199 284 284


    • Contact emergency number: 112
    • For mental health support, contact 113 Zelfmoordpreventie: 0800 0113


    • Contact emergency number: 112
    • For mental health support, contact Sos Voz Amiga: 21 354 45 45, 91 280 26 69, or 96 352 46 60

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