What are the contraindications for Benperidol?


Benperidol is contraindicated in patients with known hypersensitivity to the drug or any components of its formulation. Reactions may include rash, itching, swelling, and bronchospasm.

Parkinson’s disease

Benperidol can worsen symptoms of Parkinson’s disease due to its blockade of dopamine receptors. It is therefore contraindicated in patients with Parkinson’s disease.


Benperidol may worsen symptoms of depression and increase the risk of suicidal thoughts and behaviors. It should not be used in patients with severe depression or suicidal ideation.

Cardiovascular disease

Due its potential to prolong the QT interval, benperidol is contraindicated in patients with a history of cardiac arrhythmias, congestive heart failure, or recent myocardial infarction. It can also cause orthostatic hypotension, so should be avoided in patients with uncontrolled hypertension.


Benperidol lowers the seizure threshold and should not be used in patients with epilepsy or a history of seizures.


In patients with pheochromocytoma, benperidol may lead to a hypertensive crisis due to release of catecholamines. It is therefore contraindicated in these patients.

Prostatic hyperplasia

Benperidol has anticholinergic effects and can worsen symptoms of prostatic hyperplasia like urinary retention. It should be avoided in patients with severe prostatic hypertrophy.


In elderly patients with dementia, benperidol confers an increased risk of mortality, cerebrovascular events, and parkinsonism. Due to its significant safety risks, benperidol is contraindicated for behavioral problems in elderly dementia patients.

Hepatic impairment

Due to extensive metabolism of benperidol by the liver, reduced doses or dosage adjustments are recommended in patients with hepatic impairment. However, in severe liver disease the risks may outweigh potential benefits, so use is contraindicated.

Narrow-angle glaucoma

Benperidol can cause pupillary dilatation which may precipitate an attack of narrow-angle glaucoma. It is therefore contraindicated in patients with narrow angle glaucoma.

In summary, benperidol has many contraindications due to its risk of adverse effects in certain susceptible patient populations or disease states. Caution must be exercised if benperidol is used, and in many cases safer alternative treatments may be preferred, especially given the availability of newer atypical antipsychotics with fewer contraindications and side effects.

There are various forms of drugs available, such as tablets or liquids, and each may have a separate patient information leaflet (PIL) for different doses. It is important to refer to the PIL for the specific form and dose of the drug that you have been prescribed.

You can search for further information and PILs on websites such as: