What is the dosing for benperidol?

Oral Dosing for benperidol

Benperidol is available as oral tablets of 1 mg, 2 mg, and 5 mg. Due to its long half-life and poor bioavailability, benperidol must be administered 2-3 times daily to achieve sustained antipsychotic effect.

For schizophrenia, the initial dose is usually 2-10 mg orally 2-3 times per day. The dose is then gradually titrated based on response and tolerability to a usual dosage range of 12-60 mg/day in divided doses. Higher doses up to 200 mg/day have been used in some patients.

It may take 1-2 weeks to reach steady state and full therapeutic effect. Dosage adjustments or switching to an alternative antipsychotic may be required in nonresponsive patients or intolerable side effects. When discontinuing benperidol, gradual reduction of the dose is recommended to avoid withdrawal symptoms.

Elderly patients

In elderly patients, benperidol should be initiated at the lowest recommended dose (e.g. 1-2 mg twice daily) and titrated cautiously. Total daily doses greater than 30 mg are not recommended due to increased risk of sedation and hypotension. Renal or hepatic impairment may also require reduced doses.

CYP2D6 interactions

Benperidol is metabolized by the CYP2D6 enzyme, so inhibitors of CYP2D6 can significantly increase benperidol levels in some individuals. When administering benperidol with a CYP2D6 inhibitor, a 50% reduction of the usual dose is recommended, with close monitoring for side effects. Alternatively, a non-CYP2D6 dependent antipsychotic should be considered.

In CYP2D6 ultrarapid metabolizers, higher doses of benperidol may be required due to increased metabolism and clearance. However, high doses also increase the risks of adverse events, so close clinical monitoring is warranted. CYP2D6 metabolizer status may help guide dosing, but currently there are no definitive recommendations available due to limited research in this area.

Intramuscular dosing for benperidol

Benperidol can also be administered via intramuscular injection when oral administration is not possible. The recommended intramuscular dose is half the usual oral dose. Intramuscular benperidol has a faster onset of action, but also risks site pain, abscess formation, and erratic absorption. It is not recommended for maintenance therapy.

In summary, benperidol has a complex dosing regimen that must be carefully managed based on individual patient factors. Due to its narrow therapeutic range and long list of potential drug interactions and adverse events, close monitoring by a physician is essential, especially when treatment is initiated or the dose is changed.

There are various forms of drugs available, such as tablets or liquids, and each may have a separate patient information leaflet (PIL) for different doses. It is important to refer to the PIL for the specific form and dose of the drug that you have been prescribed.

You can search for further information and PILs on websites such as:

  • The British National Formulary (BNF)
  • Electronic medicines compendium (emc)
  • The National Library of Medicine's DailyMed
  • The Food and Drug Administration (FDA) 
  • Different drug forms like tablets or liquids have specific patient information leaflets (PIL) for various doses. Refer to the PIL for your prescribed drug form and dose.

    Search for PILs on websites like:


    • ANSM (Agence nationale de sécurité du médicament et des produits de santé): ansm.sante.fr


    • AEMPS (Agencia Española de Medicamentos y Productos Sanitarios): aemps.gob.es


    • BfArM (Bundesinstitut für Arzneimittel und Medizinprodukte): bfarm.de


    For questions about your medication:

    • Consult your doctor, a healthcare professional, or a pharmacist


    • Contact SOS Médecins: 3624
    • For mental health support, contact SOS Suicide: 01 45 39 40 00

    Belgium (French)

    Switzerland (French)

    • La Main Tendue: 143
    • Website: 143.ch

    Canada (French)

    • Centre de prévention du suicide du Québec: 1 866 APPELLE (1 866 277-3553)
    • Website: cpsquebec.ca


    • Contact emergency number: 112
    • For mental health support, contact Teléfono de la Esperanza: 717 003 717


    • Contact emergency number: 112
    • For mental health support, contact Telefonseelsorge: 0800 111 0 111 or 0800 111 0 222


    • Contact emergency number: 112
    • For mental health support, contact Telefono Amico: 199 284 284


    • Contact emergency number: 112
    • For mental health support, contact 113 Zelfmoordpreventie: 0800 0113


    • Contact emergency number: 112
    • For mental health support, contact Sos Voz Amiga: 21 354 45 45, 91 280 26 69, or 96 352 46 60

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