What is the most common side effect of amitriptyline?

Amitriptyline is a medication that belongs to the class of drugs known as tricyclic antidepressants. While it is effective in treating depression, chronic pain, and other conditions, it can also cause a range of side effects. One of the most common side effects of amitriptyline is drowsiness, which can affect up to 40% of people taking the medication.

Drowsiness:

Drowsiness is the most common side effect of amitriptyline, affecting up to 40% of people taking the medication. This can be particularly problematic for people who need to be alert and focused during the day. However, drowsiness tends to improve over time as the body adjusts to the medication. Studies have shown that taking amitriptyline at night can help reduce drowsiness during the day.

Dry Mouth:

Dry mouth is another common side effect of amitriptyline, affecting up to 30% of people taking the medication. This can cause discomfort and increase the risk of dental problems. Drinking water frequently, chewing gum, and avoiding alcohol and caffeine can help reduce the symptoms of dry mouth.

Weight Gain:

Weight gain is a common side effect of amitriptyline, affecting up to 25% of people taking the medication. This can be particularly problematic for people who are already overweight or obese. Studies have shown that regular exercise and a healthy diet can help reduce the risk of weight gain while taking amitriptyline.

Blurred Vision:

Blurred vision is another common side effect of amitriptyline, affecting up to 15% of people taking the medication. This can cause difficulty seeing clearly, particularly when reading or driving. If you experience blurred vision while taking amitriptyline, it is important to talk to your doctor to rule out any underlying medical conditions.

While these side effects are common, they tend to improve over time as the body adjusts to the medication. It is important to talk to your doctor if you experience any side effects while taking amitriptyline, as they may be able to adjust your dosage or recommend other strategies to help manage your symptoms.


There are various forms of drugs available, such as tablets or liquids, and each may have a separate patient information leaflet (PIL) for different doses. It is important to refer to the PIL for the specific form and dose of the drug that you have been prescribed.

You can search for further information and PILs on websites such as: