Who should not take bupropion?

Bupropion is an antidepressant medication that can be effective for treating depression, smoking cessation, and other conditions. However, there are certain individuals who should not take bupropion or who should use caution when taking the medication. Here are some groups of people who should not take bupropion:

  1. Individuals with a history of seizures:
    Bupropion may lower the seizure threshold and increase the risk of seizures, particularly in individuals who have a history of seizures or other conditions that may increase the risk of seizures. Therefore, bupropion is contraindicated in individuals with a seizure disorder or a history of seizures.
  2. Individuals with an eating disorder:
    Bupropion may increase the risk of seizures, particularly in individuals with an eating disorder such as bulimia or anorexia nervosa. Therefore, bupropion is contraindicated in individuals with a current or prior diagnosis of an eating disorder.
  3. Individuals who are allergic to bupropion or any of its components:
    Bupropion may cause an allergic reaction in some individuals, particularly those who are allergic to bupropion or any of its components. Therefore, bupropion should not be taken by individuals who are allergic to the medication.
  4. Individuals taking certain medications:
    Bupropion may interact with certain medications, such as monoamine oxidase inhibitors (MAOIs), and may increase the risk of serious side effects such as seizures, high blood pressure, and serotonin syndrome. Therefore, bupropion should not be taken by individuals taking MAOIs or other medications that interact with bupropion.
  5. Individuals with a history of bipolar disorder:
    Bupropion may increase the risk of mania or hypomania, particularly in individuals with a history of bipolar disorder. Therefore, bupropion should be used with caution in individuals with a history of bipolar disorder or other mood disorders.

It is important to only take bupropion as prescribed by a healthcare provider and to follow their instructions carefully. If you have any questions or concerns about your medication regimen, it is important to discuss these with your healthcare provider.


There are various forms of drugs available, such as tablets or liquids, and each may have a separate patient information leaflet (PIL) for different doses. It is important to refer to the PIL for the specific form and dose of the drug that you have been prescribed.

You can search for further information and PILs on websites such as:

  • The British National Formulary (BNF)
  • Electronic medicines compendium (emc)
  • The National Library of Medicine's DailyMed
  • The Food and Drug Administration (FDA) 
  • Different drug forms like tablets or liquids have specific patient information leaflets (PIL) for various doses. Refer to the PIL for your prescribed drug form and dose.

    Search for PILs on websites like:

    France

    • ANSM (Agence nationale de sécurité du médicament et des produits de santé): ansm.sante.fr

    Spain

    • AEMPS (Agencia Española de Medicamentos y Productos Sanitarios): aemps.gob.es

    Germany

    • BfArM (Bundesinstitut für Arzneimittel und Medizinprodukte): bfarm.de

    Italy

    For questions about your medication:

    • Consult your doctor, a healthcare professional, or a pharmacist

    France

    • Contact SOS Médecins: 3624
    • For mental health support, contact SOS Suicide: 01 45 39 40 00

    Belgium (French)

    Switzerland (French)

    • La Main Tendue: 143
    • Website: 143.ch

    Canada (French)

    • Centre de prévention du suicide du Québec: 1 866 APPELLE (1 866 277-3553)
    • Website: cpsquebec.ca

    Spain

    • Contact emergency number: 112
    • For mental health support, contact Teléfono de la Esperanza: 717 003 717

    Germany

    • Contact emergency number: 112
    • For mental health support, contact Telefonseelsorge: 0800 111 0 111 or 0800 111 0 222

    Italy

    • Contact emergency number: 112
    • For mental health support, contact Telefono Amico: 199 284 284

    Netherlands

    • Contact emergency number: 112
    • For mental health support, contact 113 Zelfmoordpreventie: 0800 0113

    Portugal

    • Contact emergency number: 112
    • For mental health support, contact Sos Voz Amiga: 21 354 45 45, 91 280 26 69, or 96 352 46 60

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