Who should not take mirtazapine?

Mirtazapine may not be suitable for everyone, and there are certain individuals who should not take this medication. Some examples include:

  1. Allergy to mirtazapine: People who are allergic to mirtazapine or any of its ingredients should not take this medication.
  2. Use of MAO inhibitors: Mirtazapine should not be taken by individuals who are currently taking or have recently taken a monoamine oxidase inhibitor (MAOI) medication, as this combination can cause serious and potentially life-threatening side effects.
  3. Liver disease: Mirtazapine is broken down by the liver, so individuals with severe liver disease may not be able to process the medication properly.
  4. Pregnancy and breastfeeding: The safety of mirtazapine during pregnancy and breastfeeding has not been thoroughly studied, and it may not be safe for these populations.
  5. Children: Mirtazapine is not approved for use in children under the age of 18.

It is important to discuss any medical conditions, allergies, or medications you are taking with your healthcare provider before starting mirtazapine or any other medication. Your healthcare provider can help determine whether mirtazapine is a safe and appropriate treatment option for you.


There are various forms of drugs available, such as tablets or liquids, and each may have a separate patient information leaflet (PIL) for different doses. It is important to refer to the PIL for the specific form and dose of the drug that you have been prescribed.

You can search for further information and PILs on websites such as:

  • The British National Formulary (BNF)
  • Electronic medicines compendium (emc)
  • The National Library of Medicine's DailyMed
  • The Food and Drug Administration (FDA) 
  • Different drug forms like tablets or liquids have specific patient information leaflets (PIL) for various doses. Refer to the PIL for your prescribed drug form and dose.

    Search for PILs on websites like:

    France

    • ANSM (Agence nationale de sécurité du médicament et des produits de santé): ansm.sante.fr

    Spain

    • AEMPS (Agencia Española de Medicamentos y Productos Sanitarios): aemps.gob.es

    Germany

    • BfArM (Bundesinstitut für Arzneimittel und Medizinprodukte): bfarm.de

    Italy

    For questions about your medication:

    • Consult your doctor, a healthcare professional, or a pharmacist

    France

    • Contact SOS Médecins: 3624
    • For mental health support, contact SOS Suicide: 01 45 39 40 00

    Belgium (French)

    Switzerland (French)

    • La Main Tendue: 143
    • Website: 143.ch

    Canada (French)

    • Centre de prévention du suicide du Québec: 1 866 APPELLE (1 866 277-3553)
    • Website: cpsquebec.ca

    Spain

    • Contact emergency number: 112
    • For mental health support, contact Teléfono de la Esperanza: 717 003 717

    Germany

    • Contact emergency number: 112
    • For mental health support, contact Telefonseelsorge: 0800 111 0 111 or 0800 111 0 222

    Italy

    • Contact emergency number: 112
    • For mental health support, contact Telefono Amico: 199 284 284

    Netherlands

    • Contact emergency number: 112
    • For mental health support, contact 113 Zelfmoordpreventie: 0800 0113

    Portugal

    • Contact emergency number: 112
    • For mental health support, contact Sos Voz Amiga: 21 354 45 45, 91 280 26 69, or 96 352 46 60

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