Does mirtazapine affect memory?

Mirtazapine is a medication commonly used to treat depression and other mental health conditions. While it is generally considered to be safe and effective, there is some evidence to suggest that mirtazapine may have an impact on memory.

Effects on Memory: Mild and Varied

Some studies have found that mirtazapine can cause mild cognitive impairment, including deficits in working memory and attention. However, other studies have not found significant cognitive effects associated with mirtazapine use.

Individual Variability

It is important to note that cognitive impairment is a potential side effect of many medications, including antidepressants. However, the risk and severity of cognitive impairment can vary depending on the individual, the medication, and other factors.

Talk to Your Healthcare Provider

If you have concerns about the potential impact of mirtazapine on memory or other cognitive functions, it is important to discuss these concerns with your healthcare provider. They can help you weigh the potential risks and benefits of the medication and determine the best course of treatment for your individual needs.

Positive Effects on Emotional Memory

Interestingly, a different study found that mirtazapine increased memory for likeable versus dislikeable self-relevant information, suggesting an induction of positive bias in emotional memory. These effects may be important for understanding the neuropsychological mechanisms of antidepressant action in both anxiety and depressive disorders.


Overall, while mirtazapine may have mild effects on memory and cognition, the risk and severity can vary from person to person. It is important to work closely with a healthcare provider when taking mirtazapine or any other medication to ensure that it is being used safely and effectively.

There are various forms of drugs available, such as tablets or liquids, and each may have a separate patient information leaflet (PIL) for different doses. It is important to refer to the PIL for the specific form and dose of the drug that you have been prescribed.

You can search for further information and PILs on websites such as: