Why is duloxetine taken at night?

Duloxetine can be taken at any time of day, but some people may find it beneficial to take it at night. There are several reasons why someone may choose to take duloxetine at night:

  1. Drowsiness: Duloxetine can cause drowsiness as a side effect, particularly when first starting the medication. Taking it at night can help minimize the impact of this side effect on daily activities.
  2. Insomnia: While duloxetine can cause drowsiness in some people, it can also cause insomnia or difficulty sleeping in others. Taking it at night may help alleviate insomnia symptoms.
  3. Convenience: For some people, taking duloxetine at night may be more convenient than taking it during the day. This can be particularly true for people who have busy schedules or who have difficulty remembering to take medication during the day.

It’s important to note that the timing of medication can vary depending on individual factors and preferences. If you are considering taking duloxetine at night, talk to your healthcare provider. They can provide guidance on the best timing for your individual needs and monitor your symptoms and side effects while taking the medication.


There are various forms of drugs available, such as tablets or liquids, and each may have a separate patient information leaflet (PIL) for different doses. It is important to refer to the PIL for the specific form and dose of the drug that you have been prescribed.

You can search for further information and PILs on websites such as:

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