Will duloxetine make you gain weight?

Duloxetine can cause weight changes in some people, but the effects on weight can vary from person to person. Some people may experience weight loss while taking duloxetine, while others may experience weight gain.

Weight gain is a potential side effect of duloxetine, but it is not a common side effect. According to clinical studies, less than 1% of people taking duloxetine experienced weight gain as a side effect. However, weight gain can still occur in some people, and it’s important to be aware of this potential side effect.

If you are concerned about the potential for weight gain while taking duloxetine, talk to your healthcare provider. They can provide guidance on ways to minimize the risk of weight gain, such as making dietary changes and increasing physical activity. Additionally, regular monitoring of weight and other vital signs may be recommended while taking duloxetine.

It’s important to note that mental health conditions, such as depression and anxiety, can also impact weight. Therefore, it can be difficult to determine whether any weight changes are directly related to duloxetine or to the underlying mental health condition. If you have concerns about changes in your weight while taking duloxetine, talk to your healthcare provider. They can help determine the cause of any changes and provide guidance on the best course of action.


There are various forms of drugs available, such as tablets or liquids, and each may have a separate patient information leaflet (PIL) for different doses. It is important to refer to the PIL for the specific form and dose of the drug that you have been prescribed.

You can search for further information and PILs on websites such as: