Why take Lexapro and Wellbutrin together?

When it comes to treating depression and other mental health conditions, sometimes a single medication may not address all the symptoms a patient is experiencing. This is where combination therapy can come into play. Lexapro (escitalopram) and Wellbutrin (bupropion) are two medications that are occasionally prescribed together to provide a more comprehensive treatment approach. But why combine these two drugs, and what are the potential benefits and considerations? Let’s dive in.

The Mechanism Behind the Medications

To understand why these two might be used in tandem, it’s important to look at how they work individually.

Lexapro (Escitalopram)

Lexapro is a selective serotonin reuptake inhibitor (SSRI). It works by increasing the levels of serotonin, a neurotransmitter associated with mood regulation, in the brain. This can help alleviate symptoms of depression and anxiety. However, for some patients, SSRIs can also lead to side effects like sexual dysfunction, weight gain, and sometimes, a blunting of emotions or energy levels.

Wellbutrin (Bupropion)

Wellbutrin, on the other hand, is a norepinephrine-dopamine reuptake inhibitor (NDRI). It acts on the levels of norepinephrine and dopamine, neurotransmitters that play key roles in mood and energy. Wellbutrin is often noted for its stimulating effects and lower risk of sexual side effects, which can be beneficial for patients who experience lethargy or sexual dysfunction on SSRIs.

The Combined Approach

When Lexapro and Wellbutrin are prescribed together, the goal is to target a broader range of neurotransmitters that can be involved in depression. Here are some reasons healthcare providers might consider this combination:

Complementary Action

Combining the serotonin-boosting effects of Lexapro with the dopamine and norepinephrine effects of Wellbutrin can provide a more balanced neurotransmitter environment, potentially leading to improved treatment outcomes for patients with depression.

Side Effect Management

For patients who experience certain side effects from Lexapro, such as sexual dysfunction or weight gain, adding Wellbutrin can sometimes counteract these issues.

Enhanced Efficacy

Some patients may not respond adequately to an SSRI alone and may experience an enhanced therapeutic effect with the addition of Wellbutrin.

Addressing Multiple Symptoms

Wellbutrin can help with attention and focus issues, which are sometimes present in depression, while Lexapro can be more effective for anxiety, creating a comprehensive treatment plan.

Clinical Considerations

Despite the potential benefits, there are important considerations to take into account:

Risk of Side Effects

When medications like Lexapro and Wellbutrin are combined, there is an inherent increase in the risk of side effects due to the interaction of different drugs within the body. The range and severity of side effects can considerably vary from one patient to another, influenced by individual tolerance levels and biological responses. It’s crucial to be aware of the potential side effects, which may include, but are not limited to:

  • Increased anxiety or jitteriness
  • Insomnia or changes in sleeping patterns
  • Nausea and digestive discomfort
  • Headaches
  • Dry mouth
  • Dizziness
  • Sexual dysfunction
  • Changes in appetite or weight
  • Increased blood pressure

Patients should be closely monitored by healthcare professionals to manage and mitigate these risks effectively. Any new or worsening side effects should be reported to a healthcare provider immediately.

Monitoring and Adjustment

It’s crucial for patients to be closely monitored by their healthcare provider to find the optimal dosing and to ensure the safety of the combination.

Individual Response

Not all patients will respond to medication combinations in the same way, and it may take time to determine the most effective treatment strategy.


Taking Lexapro and Wellbutrin together can be a strategic approach to treating depression, particularly when a patient’s symptoms are complex or when they have not fully responded to monotherapy. However, it’s essential that this combination be guided by a healthcare provider who can evaluate the risks and benefits for each individual.

There are various forms of drugs available, such as tablets or liquids, and each may have a separate patient information leaflet (PIL) for different doses. It is important to refer to the PIL for the specific form and dose of the drug that you have been prescribed.

You can search for further information and PILs on websites such as: