What is the most common side effect of sertraline?

If you have been prescribed sertraline, you may be wondering about the potential side effects of this medication. Sertraline is a selective serotonin reuptake inhibitor (SSRI) that is commonly used to treat depression, anxiety disorders, obsessive-compulsive disorder (OCD), post-traumatic stress disorder (PTSD), and premenstrual dysphoric disorder (PMDD). While sertraline can be very effective at treating these conditions, it can also cause side effects, and one of the most common side effects of sertraline is nausea.

Nausea is a feeling of discomfort in the stomach, often accompanied by the urge to vomit. It can be caused by a variety of factors, including motion sickness, a viral infection, or certain medications. In the case of sertraline, nausea is a common side effect that can occur in up to 30% of individuals taking the medication.

The exact mechanism by which sertraline causes nausea is not well understood. However, it is believed to be related to the drug’s effect on serotonin levels in the brain and gut. Serotonin is a neurotransmitter that plays a role in regulating mood, appetite, and digestion. By increasing the levels of serotonin in the brain, sertraline can help to improve mood and reduce anxiety. However, it can also affect the levels of serotonin in the gut, which can lead to nausea and other digestive issues.

While nausea is the most common side effect of sertraline, it is usually mild and goes away on its own after a few days or weeks. However, if you experience severe or persistent nausea, it is important to talk to your doctor. They may be able to adjust your dosage or switch you to a different medication to help alleviate your symptoms.

In addition to nausea, sertraline can cause a variety of other side effects, including:

Most of these side effects are mild and go away on their own after a few days or weeks. However, some individuals may experience more severe or persistent side effects that require medical attention. If you experience any severe or persistent side effects while taking sertraline, it is important to contact your doctor right away.

To help alleviate nausea and other digestive issues caused by sertraline, there are a few things you can do. First, try taking the medication with food. This can help to slow down the absorption of the medication and reduce the likelihood of nausea. You can also try taking smaller, more frequent doses throughout the day instead of one large dose. This can help to reduce the amount of medication in your system at any one time, which can help to alleviate nausea.

In addition to these strategies, there are also a variety of over-the-counter medications that can help to alleviate nausea, such as antacids or anti-nausea medications. However, it is important to talk to your doctor before taking any over-the-counter medications to make sure they are safe and won’t interact with the sertraline.

While nausea is the most common side effect of sertraline, it is important to note that not everyone will experience this side effect. In fact, some individuals may not experience any side effects at all. It is also important to remember that the benefits of taking sertraline for the treatment of depression, anxiety, and other conditions often outweigh the potential side effects.

In conclusion, if you have been prescribed sertraline, it is important to be aware of the potential side effects of this medication. While nausea is the most common side effect of sertraline, it is usually mild and goes away on its own after a few days or weeks. However, if you experience severe or persistent nausea, it is important to talk to your doctor. They may be able to adjust your dosage or switch you to a different medication to help alleviate your symptoms. It is also important to remember that the benefits of taking sertraline for the treatment of depression, anxiety, OCD, PTSD, and PMDD often outweigh the potential side effects.


There are various forms of drugs available, such as tablets or liquids, and each may have a separate patient information leaflet (PIL) for different doses. It is important to refer to the PIL for the specific form and dose of the drug that you have been prescribed.

You can search for further information and PILs on websites such as:

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