Can bupropion cause bipolar?

There is some evidence to suggest that bupropion may increase the risk of manic or hypomanic episodes in individuals who have a history of bipolar disorder or who are at risk for bipolar disorder.

Bupropion is classified as an atypical antidepressant or dopamine and norepinephrine reuptake inhibitor (DNRI), as it works by blocking the reuptake of dopamine and norepinephrine in the brain. These neurotransmitters are involved in regulating mood, motivation, and other brain functions.

While bupropion can be effective in treating depression and other conditions, it may also increase the risk of manic or hypomanic episodes in some individuals. This risk appears to be higher in individuals with a prior history of bipolar disorder, as well as those with a family history of bipolar disorder.

If you have a history of bipolar disorder or other mood disorders, it is important to discuss the risks and benefits of bupropion with your healthcare provider before starting the medication. They may recommend other treatment options or closely monitor you for signs of mood changes while taking bupropion.

If you experience any changes in mood or other symptoms while taking bupropion, it is important to report these to your healthcare provider. They can help determine the underlying cause and recommend appropriate treatment options.

There are various forms of drugs available, such as tablets or liquids, and each may have a separate patient information leaflet (PIL) for different doses. It is important to refer to the PIL for the specific form and dose of the drug that you have been prescribed.

You can search for further information and PILs on websites such as: