How does agomelatine make you feel?

Agomelatine is an antidepressant medication that works by modulating the activity of the neurotransmitters melatonin and serotonin in the brain. Its effects on mood and overall well-being can vary from person to person, and it may take several weeks to feel the full effects of the medication.

In general, agomelatine is reported to have a positive effect on mood and may help to reduce symptoms of depression and anxiety, such as persistent sadness or worry, loss of interest in activities, and disrupted sleep patterns. Some individuals may also experience improvements in energy levels and overall sense of well-being.

It is important to note that like all medications, agomelatine can have side effects, and not all individuals will respond to the medication in the same way. Common side effects of agomelatine include nausea, headache, and dizziness, although these side effects are generally mild and temporary.

If an individual is experiencing concerning changes in mood or behavior while taking agomelatine, they should speak with their healthcare provider. The healthcare provider may adjust the dosage or consider switching to a different medication to help manage side effects and improve overall well-being.


There are various forms of drugs available, such as tablets or liquids, and each may have a separate patient information leaflet (PIL) for different doses. It is important to refer to the PIL for the specific form and dose of the drug that you have been prescribed.

You can search for further information and PILs on websites such as:

  • The British National Formulary (BNF)
  • Electronic medicines compendium (emc)
  • The National Library of Medicine's DailyMed
  • The Food and Drug Administration (FDA) 
  • Different drug forms like tablets or liquids have specific patient information leaflets (PIL) for various doses. Refer to the PIL for your prescribed drug form and dose.

    Search for PILs on websites like:

    France

    • ANSM (Agence nationale de sécurité du médicament et des produits de santé): ansm.sante.fr

    Spain

    • AEMPS (Agencia Española de Medicamentos y Productos Sanitarios): aemps.gob.es

    Germany

    • BfArM (Bundesinstitut für Arzneimittel und Medizinprodukte): bfarm.de

    Italy

    For questions about your medication:

    • Consult your doctor, a healthcare professional, or a pharmacist

    France

    • Contact SOS Médecins: 3624
    • For mental health support, contact SOS Suicide: 01 45 39 40 00

    Belgium (French)

    Switzerland (French)

    • La Main Tendue: 143
    • Website: 143.ch

    Canada (French)

    • Centre de prévention du suicide du Québec: 1 866 APPELLE (1 866 277-3553)
    • Website: cpsquebec.ca

    Spain

    • Contact emergency number: 112
    • For mental health support, contact Teléfono de la Esperanza: 717 003 717

    Germany

    • Contact emergency number: 112
    • For mental health support, contact Telefonseelsorge: 0800 111 0 111 or 0800 111 0 222

    Italy

    • Contact emergency number: 112
    • For mental health support, contact Telefono Amico: 199 284 284

    Netherlands

    • Contact emergency number: 112
    • For mental health support, contact 113 Zelfmoordpreventie: 0800 0113

    Portugal

    • Contact emergency number: 112
    • For mental health support, contact Sos Voz Amiga: 21 354 45 45, 91 280 26 69, or 96 352 46 60

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