How does agomelatine make you feel?

Agomelatine is an antidepressant medication that works by modulating the activity of the neurotransmitters melatonin and serotonin in the brain. Its effects on mood and overall well-being can vary from person to person, and it may take several weeks to feel the full effects of the medication.

In general, agomelatine is reported to have a positive effect on mood and may help to reduce symptoms of depression and anxiety, such as persistent sadness or worry, loss of interest in activities, and disrupted sleep patterns. Some individuals may also experience improvements in energy levels and overall sense of well-being.

It is important to note that like all medications, agomelatine can have side effects, and not all individuals will respond to the medication in the same way. Common side effects of agomelatine include nausea, headache, and dizziness, although these side effects are generally mild and temporary.

If an individual is experiencing concerning changes in mood or behavior while taking agomelatine, they should speak with their healthcare provider. The healthcare provider may adjust the dosage or consider switching to a different medication to help manage side effects and improve overall well-being.


There are various forms of drugs available, such as tablets or liquids, and each may have a separate patient information leaflet (PIL) for different doses. It is important to refer to the PIL for the specific form and dose of the drug that you have been prescribed.

You can search for further information and PILs on websites such as: