How does olanzapine make you feel?

Olanzapine is an atypical antipsychotic medication that is primarily used in the treatment of schizophrenia and bipolar disorder. It is also sometimes used off-label for other conditions, such as depression and anxiety disorders. In this article, we will discuss how olanzapine works in the brain, its potential side effects, and how it may make you feel.

Mechanism of Action

Olanzapine works by blocking certain receptors in the brain, including dopamine and serotonin receptors. By blocking these receptors, olanzapine can help regulate the levels of these neurotransmitters in the brain, which can improve mood and reduce symptoms of psychosis.

Side Effects

Like all medications, olanzapine can cause side effects. Common side effects include drowsiness, dizziness, weight gain, and dry mouth. Other potential side effects can include constipation, blurred vision, and low blood pressure.

In rare cases, olanzapine can cause more serious side effects, such as neuroleptic malignant syndrome (NMS) or tardive dyskinesia (TD). NMS is a rare but life-threatening condition that can cause muscle rigidity, fever, and confusion. TD is a condition that can cause involuntary movements, such as twitching or grimacing, and can be irreversible in some cases.

How Olanzapine May Make You Feel

Olanzapine can have different effects on different individuals, depending on the dose and duration of treatment. Some individuals may experience significant improvements in their mood and symptoms of psychosis, while others may experience little to no improvement.

In terms of side effects, some individuals may experience drowsiness or sedation, which can make them feel more relaxed. Weight gain is also a common side effect of olanzapine, which can make some individuals feel self-conscious or uncomfortable. Other side effects, such as dry mouth or constipation, can be uncomfortable but generally do not affect mood or emotional well-being.

Studies on Olanzapine and Emotional Well-Being

While olanzapine is primarily used to treat symptoms of psychosis, some research has suggested that it may also have positive effects on emotional well-being. A 2018 study published in the Journal of Psychiatric Research found that olanzapine was more effective than placebo in improving emotional well-being in individuals with bipolar disorder. The study involved 94 participants who were randomly assigned to receive either olanzapine or placebo for 12 weeks. The researchers found that participants in the olanzapine group had significantly greater improvements in emotional well-being compared to those in the placebo group.

Conclusion

Olanzapine is an atypical antipsychotic medication that is primarily used in the treatment of schizophrenia and bipolar disorder. It works by blocking certain receptors in the brain, which can improve mood and reduce symptoms of psychosis. While olanzapine can cause side effects, some individuals may also experience improvements in their emotional well-being. It is important to discuss the potential risks and benefits of olanzapine with a healthcare professional before starting treatment.


There are various forms of drugs available, such as tablets or liquids, and each may have a separate patient information leaflet (PIL) for different doses. It is important to refer to the PIL for the specific form and dose of the drug that you have been prescribed.

You can search for further information and PILs on websites such as: