Can agomelatine make anxiety worse?

While agomelatine is generally well-tolerated by most individuals, it is possible for it to cause or worsen anxiety in some cases. Anxiety is listed as a possible side effect of agomelatine, although it is not a common one.

Individuals who experience worsening anxiety or other concerning changes in mood or behavior while taking agomelatine should speak with their healthcare provider. The healthcare provider may adjust the dosage or consider switching to a different medication to help manage side effects and improve overall well-being.

It is important to note that not all individuals with anxiety or depression will respond to agomelatine, and it may not be the best choice of medication for everyone. The decision to use agomelatine or any other medication should be made in consultation with a healthcare provider, who can help determine the most appropriate treatment plan based on individual needs and medical history.


There are various forms of drugs available, such as tablets or liquids, and each may have a separate patient information leaflet (PIL) for different doses. It is important to refer to the PIL for the specific form and dose of the drug that you have been prescribed.

You can search for further information and PILs on websites such as:

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