Lamotrigine is primarily used to treat epilepsy and bipolar disorder, but some research has suggested that it may have benefits for individuals with anxiety disorders. While it is not typically used as a first-line treatment for anxiety, there has been some interest in exploring its potential as an alternative treatment option.
One study, published in the Journal of Clinical Psychiatry in 2005, found that lamotrigine was effective in reducing anxiety symptoms in individuals with generalized anxiety disorder (GAD). The study was a randomized, double-blind, placebo-controlled trial that involved 24 individuals with GAD who were randomly assigned to receive either lamotrigine or placebo for 8 weeks. The results showed that lamotrigine was more effective than placebo in reducing anxiety symptoms, as measured by the Hamilton Anxiety Rating Scale (HAM-A).
Another study, published in the Journal of Affective Disorders in 2010, found that lamotrigine may be effective in reducing symptoms of social anxiety disorder (SAD). The study involved 30 individuals with SAD who were randomly assigned to receive either lamotrigine or placebo for 12 weeks. The results showed that lamotrigine was more effective than placebo in reducing symptoms of social anxiety, as measured by the Liebowitz Social Anxiety Scale (LSAS).
While these studies suggest that lamotrigine may have some benefits for individuals with anxiety disorders, it is important to note that more research is needed to fully understand its potential as a treatment option. Additionally, lamotrigine can cause side effects, including skin rash, headache, dizziness, and nausea, and can increase the risk of suicidal thoughts or behavior in some individuals. As with any medication, it is important to discuss the potential benefits and risks with a doctor or healthcare provider before starting treatment. Individuals with anxiety disorders should also consider other treatment options, such as therapy, lifestyle changes, or other medications, depending on their individual symptoms and needs.