Is venlafaxine hard to get off of?

Venlafaxine is an antidepressant medication that is commonly used to treat depression, anxiety, and other mental health conditions. While venlafaxine can be effective in treating these conditions, some individuals may experience withdrawal symptoms when they try to stop taking the medication. In this article, we will explore the potential challenges of discontinuing venlafaxine and examine the available research on the topic.

Overview of Venlafaxine Withdrawal

Venlafaxine withdrawal occurs when an individual stops taking the medication or reduces their dose too quickly. Withdrawal symptoms can vary in severity and duration, but may include:

The severity of withdrawal symptoms can depend on a number of factors, including the individual’s dosage, how long they have been taking the medication, and their individual sensitivity to the drug. Withdrawal symptoms can last anywhere from a few days to several weeks or months.

Why is Venlafaxine Hard to Get Off Of?

Venlafaxine is classified as a serotonin-norepinephrine reuptake inhibitor (SNRI), which means that it works by increasing levels of the neurotransmitters serotonin and norepinephrine in the brain. These neurotransmitters are involved in regulating mood, sleep, and other bodily functions. When an individual stops taking venlafaxine or reduces their dose too quickly, it can disrupt the delicate balance of neurotransmitters in the brain, leading to withdrawal symptoms.

Venlafaxine has a relatively short half-life, which means that it is metabolized and eliminated from the body relatively quickly. This can make withdrawal symptoms more intense and immediate than with some other antidepressant medications. Additionally, venlafaxine can cause rebound symptoms when it is discontinued, which means that the symptoms that the medication was originally prescribed for may return or worsen after stopping the medication.

Managing Venlafaxine Withdrawal

The best way to manage venlafaxine withdrawal is to work with a healthcare provider to gradually taper off the medication. This can help to minimize withdrawal symptoms and reduce the risk of rebound symptoms. Tapering off venlafaxine typically involves gradually reducing the dose over a period of several weeks or months, depending on the individual’s dosage and how long they have been taking the medication.

Other strategies that may be helpful in managing venlafaxine withdrawal include:

  • Staying hydrated and eating a healthy diet
  • Getting enough sleep and rest
  • Engaging in regular exercise or physical activity
  • Practicing relaxation techniques, such as deep breathing or meditation
  • Seeking support from friends, family, or a mental health professional

It is important to note that discontinuing venlafaxine or any other medication should always be done under the guidance of a healthcare provider. Abruptly stopping the medication or reducing the dose too quickly can lead to serious withdrawal symptoms and potential complications.

Research on Venlafaxine Withdrawal

Several studies have examined the potential challenges of discontinuing venlafaxine. A study published in the Journal of Affective Disorders found that venlafaxine withdrawal was more severe and lasted longer than withdrawal from other antidepressant medications. Another study published in the Journal of Clinical Psychopharmacology found that tapering off venlafaxine over a longer period of time was associated with fewer withdrawal symptoms.

Overall, the available research suggests that venlafaxine withdrawal can be challenging and may require a carefully planned tapering schedule to minimize symptoms. It is important for individuals who are considering discontinuing venlafaxine to work closely with a healthcare provider to develop a safe and effective plan for tapering off the medication.


In conclusion, venlafaxine withdrawal can be a challenging experience for some individuals. The medication’s short half-life and impact on neurotransmitter levels in the brain can lead to withdrawal symptoms that can last for several weeks or months. However, with careful management and guidance from a healthcare provider, it is possible to safely taper off venlafaxine and minimize the risk of withdrawal symptoms. If you are considering discontinuing venlafaxine, it is important to discuss your options with a healthcare provider and develop a plan that is tailored to your individual needs and circumstances.

There are various forms of drugs available, such as tablets or liquids, and each may have a separate patient information leaflet (PIL) for different doses. It is important to refer to the PIL for the specific form and dose of the drug that you have been prescribed.

You can search for further information and PILs on websites such as: