What happens when you stop taking bupropion?

Quick answer: Stopping bupropion (Wellbutrin) abruptly can cause withdrawal symptoms such as anxiety, irritability, dizziness, headaches, nausea, or sleep disturbances. It may also trigger a relapse of depression or smoking cravings. Always taper gradually under medical supervision to avoid discomfort and ensure safe discontinuation.

It is important to only stop taking bupropion as directed by a healthcare provider. Suddenly stopping bupropion or reducing the dose without medical supervision can lead to withdrawal symptoms and other potential complications.

If you stop taking bupropion suddenly or miss several doses, you may experience withdrawal symptoms such as headache, dizziness, nausea, vomiting, irritability, anxiety, and sleep disturbances. These symptoms can vary in severity and duration depending on the individual and their specific circumstances.

In addition to withdrawal symptoms, stopping bupropion suddenly or without medical supervision can also increase the risk of relapse or recurrence of the condition being treated, such as depression or smoking cessation.

If you are considering stopping bupropion or have concerns about your medication regimen, it is important to discuss this with your healthcare provider. They can help develop a plan for tapering off the medication safely and effectively, or recommend alternative treatment options if needed.

Related Questions (FAQ)

How Does Bupropion XL Make You Feel?

Bupropion XL often helps people feel more motivated, energetic, and emotionally balanced without the emotional numbness seen with some SSRIs. During the first weeks, mild anxiety, insomnia, or restlessness may appear before mood and focus noticeably improve. Most users report feeling “lighter” and more alert once their body adjusts.

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Wellbutrin SR vs XL: Which Is Better for You?

Bottom line: SR and XL work about the same for depression; XL’s once-daily, smoother release often fits busy routines and may reduce peak-related side effects (jitters, nausea, headache).

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Is 300 mg of Bupropion XL Considered a High Dose?

A 300 mg daily dose of Bupropion XL is generally considered a standard therapeutic amount — not unusually high, but on the upper end of the typical range (150 mg – 450 mg/day). For most patients, it balances strong antidepressant effects with manageable side-effect risk, though it should always be monitored by a doctor.

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Why take Lexapro and Wellbutrin together?

Doctors may prescribe Lexapro (escitalopram) and Wellbutrin (bupropion) together to treat depression or anxiety more effectively. Lexapro increases serotonin levels, improving mood and calmness, while Wellbutrin boosts dopamine and norepinephrine, enhancing energy and motivation. The combination can balance emotional stability and focus while reducing sexual side effects or fatigue from SSRI therapy.

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Can you take Wellbutrin and an Antipsychotic?

Yes, Wellbutrin (bupropion) can sometimes be taken with an antipsychotic under close medical supervision. This combination may help manage both depressive and psychotic symptoms by balancing dopamine, norepinephrine, and serotonin activity. However, it increases the risk of seizures and interactions, so dosage and monitoring must be tailored by a psychiatrist.

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Is Vraylar better than Wellbutrin?

Vraylar (cariprazine) and Wellbutrin (bupropion) serve different roles—Vraylar treats bipolar disorder and schizophrenia, while Wellbutrin addresses depression and low motivation. One isn’t “better” than the other; the right choice depends on the condition being treated, side-effect tolerance, and individual response under a doctor’s supervision.

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Disclaimer: Educational content only. Always follow your doctor/pharmacist. Official patient leaflets & emergency contacts: Drug Safety Resources.