Can you take Wellbutrin and an Antipsychotic?

Dealing with complex mental health conditions often requires a multifaceted treatment approach. It’s not uncommon for healthcare providers to prescribe a combination of medications to tackle different aspects of a disorder. Today, we’re exploring the potential of combining Wellbutrin, a well-known antidepressant, with antipsychotic medications.

The Rationale Behind the Combination

Wellbutrin (bupropion) is primarily used to treat major depressive disorder and seasonal affective disorder. Its unique action as a norepinephrine-dopamine reuptake inhibitor (NDRI) sets it apart from other antidepressants. Wellbutrin can help alleviate symptoms of depression by increasing the levels of norepinephrine and dopamine.

On the other hand, antipsychotics are used to manage symptoms of psychosis which may occur in conditions like schizophrenia, bipolar disorder, or severe depression with psychotic features. They typically work by modulating neurotransmitters like dopamine, and in some cases, serotonin.

The Potential Benefits

When Wellbutrin is used in conjunction with an antipsychotic, the combination can address a broader spectrum of symptoms. For instance:

  • Enhanced Mood and Cognition: Wellbutrin may improve depressive symptoms and cognitive function, which is often a concern for patients taking antipsychotics.
  • Balanced Treatment: Antipsychotics can control symptoms like hallucinations or mania, while Wellbutrin targets depressive symptoms.
  • Reduced Sexual Side Effects: Wellbutrin is known for having a lower risk of sexual dysfunction, a common side effect of many antipsychotics.

Possible Risks and Considerations

However, combining Wellbutrin with antipsychotics isn’t without its risks:

  • Seizure Risk: Wellbutrin can lower the seizure threshold, which could be exacerbated by certain antipsychotics.
  • Pharmacokinetic Interactions: There’s potential for interactions that affect how the drugs are metabolized and cleared from the body.
  • Increased Side Effects: Side effects from both medications could be compounded when taken together.

Clinical Observations and Studies

Research on the combination of Wellbutrin with antipsychotics is limited but growing. Some studies suggest that the combination can be beneficial when closely monitored. Clinically, many patients have found success with this combination, reporting better management of their symptoms and an improved quality of life.

Real-World Application

In practice, the decision to use Wellbutrin alongside an antipsychotic comes down to a personalized approach to treatment. A healthcare provider will consider:

  • Patient History: Past responses to medications, overall health, and treatment goals.
  • Symptom Profile: The severity and types of symptoms present.
  • Monitoring: Close observation for any adverse reactions or interactions.


Combining Wellbutrin with an antipsychotic can be a viable option for some patients, providing a more comprehensive treatment strategy. However, it requires careful consideration and professional guidance. The key to success lies in personalized care, ongoing assessment, and open communication between patients and their healthcare providers.

If you’re considering this combination of medications, it’s crucial to do so under the guidance of a psychiatrist. Only a healthcare provider can assess the potential benefits and risks based on your specific circumstances.

There are various forms of drugs available, such as tablets or liquids, and each may have a separate patient information leaflet (PIL) for different doses. It is important to refer to the PIL for the specific form and dose of the drug that you have been prescribed.

You can search for further information and PILs on websites such as: