Can I take agomelatine in the morning?

Agomelatine is typically taken once daily, preferably in the evening, shortly before bedtime. This is because agomelatine can help regulate sleep-wake cycles and improve sleep quality, making it a good choice for individuals who experience disrupted sleep patterns or insomnia as a symptom of depression or anxiety.

However, in some cases, a healthcare provider may recommend taking agomelatine in the morning instead of the evening. This may be appropriate for individuals who experience drowsiness or fatigue as a side effect of agomelatine, which can interfere with daily activities.

It is important to take agomelatine at the same time each day, as directed by a healthcare provider. Agomelatine should be taken with food, as this can help improve absorption and reduce the risk of stomach upset.

Individuals should not adjust the dosage or stop taking agomelatine without first consulting with their healthcare provider, even if they begin to feel better. It may take several weeks for the full effects of agomelatine to be felt, and abruptly stopping the medication can cause withdrawal symptoms or worsening of depression or anxiety symptoms.

It is also important to follow all instructions for taking agomelatine and report any concerning side effects or changes in mood or behavior to a healthcare provider.


There are various forms of drugs available, such as tablets or liquids, and each may have a separate patient information leaflet (PIL) for different doses. It is important to refer to the PIL for the specific form and dose of the drug that you have been prescribed.

You can search for further information and PILs on websites such as:

  • The British National Formulary (BNF)
  • Electronic medicines compendium (emc)
  • The National Library of Medicine's DailyMed
  • The Food and Drug Administration (FDA) 
  • Different drug forms like tablets or liquids have specific patient information leaflets (PIL) for various doses. Refer to the PIL for your prescribed drug form and dose.

    Search for PILs on websites like:

    France

    • ANSM (Agence nationale de sécurité du médicament et des produits de santé): ansm.sante.fr

    Spain

    • AEMPS (Agencia Española de Medicamentos y Productos Sanitarios): aemps.gob.es

    Germany

    • BfArM (Bundesinstitut für Arzneimittel und Medizinprodukte): bfarm.de

    Italy

    For questions about your medication:

    • Consult your doctor, a healthcare professional, or a pharmacist

    France

    • Contact SOS Médecins: 3624
    • For mental health support, contact SOS Suicide: 01 45 39 40 00

    Belgium (French)

    Switzerland (French)

    • La Main Tendue: 143
    • Website: 143.ch

    Canada (French)

    • Centre de prévention du suicide du Québec: 1 866 APPELLE (1 866 277-3553)
    • Website: cpsquebec.ca

    Spain

    • Contact emergency number: 112
    • For mental health support, contact Teléfono de la Esperanza: 717 003 717

    Germany

    • Contact emergency number: 112
    • For mental health support, contact Telefonseelsorge: 0800 111 0 111 or 0800 111 0 222

    Italy

    • Contact emergency number: 112
    • For mental health support, contact Telefono Amico: 199 284 284

    Netherlands

    • Contact emergency number: 112
    • For mental health support, contact 113 Zelfmoordpreventie: 0800 0113

    Portugal

    • Contact emergency number: 112
    • For mental health support, contact Sos Voz Amiga: 21 354 45 45, 91 280 26 69, or 96 352 46 60

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