Does Trintellix Affect You Sexually? Understanding the Potential Impact

Trintellix (vortioxetine) is an atypical antidepressant that has gained attention for its potential to cause fewer sexual side effects compared to other medications in its class. In this blog post, we’ll explore how Trintellix may affect sexual function and what to expect when taking this medication.

Sexual Side Effects of Antidepressants

Sexual side effects are a common concern for individuals taking antidepressant medications. These side effects may include decreased libido, difficulty achieving orgasm, erectile dysfunction, and vaginal dryness. Many selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs) are known to cause sexual side effects in some individuals.

Vortioxetine and Sexual Function

Trintellix (vortioxetine), as an atypical antidepressant, has shown promise in causing fewer sexual side effects than other SSRIs. Vortioxetine’s unique mechanism of action, which involves both inhibition of serotonin reuptake and modulation of various serotonin receptors, may contribute to its reduced impact on sexual function.

Clinical trials have demonstrated that vortioxetine may have a lower incidence of sexual side effects compared to other antidepressants. However, it’s essential to note that individual experiences may vary, and some people may still experience sexual side effects while taking Trintellix.

Managing Sexual Side Effects

If you are experiencing sexual side effects while taking Trintellix or any other antidepressant, it’s essential to discuss your concerns with your healthcare provider. They may be able to adjust your medication dosage, recommend a different medication, or suggest additional treatments to help manage sexual side effects.

Some strategies to consider when managing sexual side effects include:

  1. Open communication: Discuss your concerns with your partner to help them understand what you’re experiencing and work together to find ways to maintain intimacy and sexual satisfaction.
  2. Adapting sexual activities: Try different sexual activities or techniques that may be less affected by your side effects, such as focusing on foreplay, using lubricants, or trying new positions.
  3. Lifestyle changes: Adopting a healthy lifestyle, including regular exercise, a balanced diet, and stress reduction, may help improve overall well-being and sexual function.


Trintellix (vortioxetine) is an atypical antidepressant that may cause fewer sexual side effects compared to other medications in its class. However, individual experiences may vary, and it’s essential to discuss any concerns with your healthcare provider to find the most appropriate treatment plan for your unique needs. Open communication, adapting sexual activities, and making healthy lifestyle changes may help in managing sexual side effects while taking antidepressant medications.

There are various forms of drugs available, such as tablets or liquids, and each may have a separate patient information leaflet (PIL) for different doses. It is important to refer to the PIL for the specific form and dose of the drug that you have been prescribed.

You can search for further information and PILs on websites such as:

  • The British National Formulary (BNF)
  • Electronic medicines compendium (emc)
  • The National Library of Medicine's DailyMed
  • The Food and Drug Administration (FDA) 
  • Different drug forms like tablets or liquids have specific patient information leaflets (PIL) for various doses. Refer to the PIL for your prescribed drug form and dose.

    Search for PILs on websites like:


    • ANSM (Agence nationale de sécurité du médicament et des produits de santé):


    • AEMPS (Agencia Española de Medicamentos y Productos Sanitarios):


    • BfArM (Bundesinstitut für Arzneimittel und Medizinprodukte):


    For questions about your medication:

    • Consult your doctor, a healthcare professional, or a pharmacist


    • Contact SOS Médecins: 3624
    • For mental health support, contact SOS Suicide: 01 45 39 40 00

    Belgium (French)

    Switzerland (French)

    • La Main Tendue: 143
    • Website:

    Canada (French)

    • Centre de prévention du suicide du Québec: 1 866 APPELLE (1 866 277-3553)
    • Website:


    • Contact emergency number: 112
    • For mental health support, contact Teléfono de la Esperanza: 717 003 717


    • Contact emergency number: 112
    • For mental health support, contact Telefonseelsorge: 0800 111 0 111 or 0800 111 0 222


    • Contact emergency number: 112
    • For mental health support, contact Telefono Amico: 199 284 284


    • Contact emergency number: 112
    • For mental health support, contact 113 Zelfmoordpreventie: 0800 0113


    • Contact emergency number: 112
    • For mental health support, contact Sos Voz Amiga: 21 354 45 45, 91 280 26 69, or 96 352 46 60

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